Clinical Observation on Juanyin Decoction Combined with Pleural Chemotherapy and Radiofrequency Hyperthermia for 36 Cases of Malignant Pleural Effusion

WANG Jingliang

doi:10.13288/j.11-2166/r.2013.15.030

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Clinical Observation on Juanyin Decoction Combined with Pleural Chemotherapy and Radiofrequency Hyperthermia for 36 Cases of Malignant Pleural Effusion

更新时间：2021-11-17

- Clinical Observation on Juanyin Decoction Combined with Pleural Chemotherapy and Radiofrequency Hyperthermia for 36 Cases of Malignant Pleural Effusion
- Journal of Traditional Chinese Medicine Vol. 54, Issue 15, Pages: 1312-1315(2013)
- 作者机构：
  
  菏泽市中医医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.15.030
  CLC： R730.5
- Published：2013
- 稿件说明：
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[1]王景良.蠲饮汤联合胸腔化疗及射频热疗治疗恶性胸腔积液36例临床观察[J].中医杂志,2013,54(15):1312-1315.

WANG Jingliang. Clinical Observation on Juanyin Decoction Combined with Pleural Chemotherapy and Radiofrequency Hyperthermia for 36 Cases of Malignant Pleural Effusion[J]. Journal of Traditional Chinese Medicine2013, 54(15): 1312-1315.
[1]王景良.蠲饮汤联合胸腔化疗及射频热疗治疗恶性胸腔积液36例临床观察[J].中医杂志,2013,54(15):1312-1315. DOI： 10.13288/j.11-2166/r.2013.15.030.

WANG Jingliang. Clinical Observation on Juanyin Decoction Combined with Pleural Chemotherapy and Radiofrequency Hyperthermia for 36 Cases of Malignant Pleural Effusion[J]. Journal of Traditional Chinese Medicine2013, 54(15): 1312-1315. DOI： 10.13288/j.11-2166/r.2013.15.030.

摘要

目的观察蠲饮汤联合胸腔化疗及射频热疗治疗恶性胸腔积液的临床疗效。方法 105例患者随机分为胸腔化疗组（于治疗第1、8、15天胸腔注射顺铂40mg）34例、胸腔化疗+热疗组（胸腔化疗同时联合射频热疗

每周2次）35例、胸腔化疗+热疗+蠲饮汤组（胸腔化疗联合热疗同时口服中药蠲饮汤

每日1剂）36例。各组均治疗3周

治疗后评价各组患者胸水疗效、生活质量疗效

于治疗前后检测T淋巴细胞亚群和自然杀伤（NK）细胞

同时观察不良反应。结果胸腔化疗组胸水疗效总有效率为38.24%、临床获益率为61.76%

生活质量疗效总有效率为32.35%;胸腔化疗+热疗组分别为65.71%、74.29%、57.14%;胸腔化疗+热疗+蠲饮汤组分别为66.69%、94.44%、80.56%

胸腔化疗+热疗+蠲饮汤组临床获益率和生活质量总有效率均高于其他两组（P<0.05或P<0.01）。胸腔化疗组T细胞亚群及NK细胞治疗前后比较差异均有统计学意义（P<0.05）;治疗后胸腔化疗+热疗+蠲饮汤组T细胞亚群及NK细胞与其他两组比较差异均有统计学意义（P<0.05或P<0.01）。结论蠲饮汤联合胸腔化疗及热疗对恶性胸腔积液患者胸水控制、生活质量和免疫功能改善均有显著疗效

三者联合有协同或叠加的治疗优势。

Abstract

Objective To observe the therapeutic effect of Juanyin Decoction （decoction to eliminate rheum） combined with pleural chemotherapy and radiofrequency hyperthermia on malignant pleural effusion. Methods Totally 105 patients were randomized into the pleural chemotherapy group of 34 cases

pleural chemotherapy + radiofrequency hyperthermia group of 35 cases and pleural chemotherapy + radiofrequency hyperthermia + Juanyin Decoction group of 36 cases. The pleural chemotherapy group was given pleural injection of 40 mg cisplatin on the 1st

8th and 15th day of treatment. The pleural chemotherapy + radiofrequency hyperthermia group was given pleural chemotherapy and radiofrequency hyperthermia twice weekly. The pleural chemotherapy + radiofrequency hyperthermia + Juanyin Decoction group was given pleural chemotherapy

radiofrequency hyperthermia and Juanyin Decoction one dose daily. The treatment lasted for 3 weeks. The efficacy of pleural effusion and quality of life （QOL） were evaluated. The T lymphocyte subsets and natural killer （NK） cells were detected and the related adverse reactions were observed before and after treatment. Results The total effective rate

clinical benefit rate and QOL efficacy in the pleural chemotherapy group was 38.24%

61.76% and 32.35% respectively. The total effective rate

clinical benefit rate and QOL efficacy in the pleural chemotherapy + radiofrequency hyperthermia group was 65.71%

74.29% and 57.14% respectively. The total effective rate

clinical benefit rate and QOL efficacy in the pleural chemotherapy + radiofrequency hyperthermia + Juanyin Decoction group was 66.69%

94.44% and 80.56% respectively. The clinical benefit rate and QOL efficacy in the pleural chemotherapy + radiofrequency hyperthermia + Juanyin Decoction group was significantly higher than those in other two groups （P<0.05 or P<0.01）. The levels of CD3+

CD4+

CD4+/CD8+ and NK cells were significantly decreased but the CD8+ level was significantly increased in the pleural chemotherapy group after treatment （P<0.05）. There were significant differences between the pleural chemotherapy + radiofrequency hyperthermia + Juanyin Decoction group and other two groups in the levels of T lymphocyte subsets and NK cells after treatment （P<0.05 or P<0.01）. Conclusion Juanyin Decoction combined with pleural chemotherapy and radiofrequency hyperthermia can obviously control pleural effusion and improve QOL and immune function. The combo therapy has a synergistic and superimposed therapeutic advantage.

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Related Institution

Guangdong Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Guangzhou University of Chinese Medicine

Jinan Vocational College of Nurisng，Shandong Pronvince

The First Affiliated Hospital of Shihezi University

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Beijing University of Chinese Medicine Third Affiliated Hospital

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