Shenfu Injection Combined with Mechanical Ventilation for 30 Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

WANG Xinying; ZHANG Hong; TIAN Hongyi; WANG Cuifeng; WANG Kexian

doi:10.13288/j.11-2166/r.2013.16.029

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Shenfu Injection Combined with Mechanical Ventilation for 30 Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

更新时间：2021-11-17

- Shenfu Injection Combined with Mechanical Ventilation for 30 Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Journal of Traditional Chinese Medicine Vol. 54, Issue 16, Pages: 1386-1389(2013)
- 作者机构：
  
  青岛市黄岛区中医医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.16.029
  CLC： R563.9
- Published：2013
- 稿件说明：
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[1]王欣英,张红,田洪义,王翠峰,王科先.参附注射液配合机械通气治疗慢性阻塞性肺疾病急性加重患者30例[J].中医杂志,2013,54(16):1386-1389.

WANG Xinying, ZHANG Hong, TIAN Hongyi, et al. Shenfu Injection Combined with Mechanical Ventilation for 30 Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. Journal of Traditional Chinese Medicine2013, 54(16): 1386-1389.
[1]王欣英,张红,田洪义,王翠峰,王科先.参附注射液配合机械通气治疗慢性阻塞性肺疾病急性加重患者30例[J].中医杂志,2013,54(16):1386-1389. DOI： 10.13288/j.11-2166/r.2013.16.029.

WANG Xinying, ZHANG Hong, TIAN Hongyi, et al. Shenfu Injection Combined with Mechanical Ventilation for 30 Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. Journal of Traditional Chinese Medicine2013, 54(16): 1386-1389. DOI： 10.13288/j.11-2166/r.2013.16.029.

摘要

目的观察参附注射液配合机械通气治疗慢性阻塞性肺疾病急性加重（AECOPD）的临床疗效。方法将60例AECOPD患者随机分为治疗组和对照组各30例。两组患者均给予有创-无创序贯机械通气和基础治疗

治疗组在上述治疗的基础上给予参附注射液

每日1次

每次60ml

静脉滴注。治疗后评价临床疗效

记录两组患者肺部感染控制窗出现时间（简称出窗）、有创机械通气时间、总机械通气时间、住ICU时间及总住院时间。检测首次出窗时间与改用无创机械通气3h后通气、循环指标

记录呼吸机相关肺炎（VAP）率、撤机失败率及死亡率。结果治疗组临床疗效总有效率为100%

对照组为86.7%

治疗组明显优于对照组（P<0.05）。治疗组和对照组首次出窗时间分别为（4.17±0.41）天和（5.50±0.80）天

治疗组明显早于对照组（P<0.01）。两组患者采用无创机械通气3h后氧分压（PaO2）、二氧化碳分压（PaCO2）均较出窗时明显改善（P<0.05）;治疗组采用无创机械通气3h后动脉血pH值较出窗时改善（P<0.05）。治疗组患者有创通气时间、总机械通气时间、住ICU时间及总住院时间明显短于对照组（P<0.05）

VAP发生率、撤机失败率及死亡率明显低于对照组（P<0.01）。结论参附注射液配合机械通气治疗AECOPD患者疗效确切

可缩短有创通气时间、住ICU时间

增加撤机成功率

降低死亡率。

Abstract

Objective To observe the therapeutic effect of Shenfu Injection [injection of Renshen（Radix et Rhizoma Ginseng） and Fuzi（Radix Aconiti Lateralis Praeparata）] combined with mechanical ventilation（MV） for acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods Sixty cases of AECOPD were randomized into the treatment group and control group

with 30 in each.Both groups were given invasive-noninvasive sequential MV and basic treatment.The treatment group was added with intravenous infusion of 60ml Shenfu Injection once daily.The therapeutic effect was evaluated after treatment.The occurrence time of pulmonary infection control window

invasive MV time

total duration of MV

intensive care unit（ICU） stay time and total hospitalization time were recorded in both groups.The first occurrence time of pulmonary infection control window and the ventilation and circulation indicators after using noninvasive MV for 3 hours were detected.The ventilator-associated pneumonia（VAP） rate

extubation failure rate and mortality were recorded.Results The total effective rate of the treatment group and control group were 100% and 86.7% respectively

with a significant difference between groups（P<0.05）.The first occurrence time of pulmonary infection control window in the treatment group and control group was（4.17±0.41） days and（5.50±0.80） days respectively

with a significant difference between groups（P<0.05）.The PaO2 and PaCO2 were significantly improved in both groups after using noninvasive MV for 3 hours（P<0.05）.The arterial pH was significantly improved in the treatment group after using noninvasive MV for 3 hours as compared with the occurrence of pulmonary infection control window（P<0.05）.The invasive MV time

total duration of MV

ICU stay time and total hospitalization time in the treatment group were significantly shorter than those in the control group（P<0.05）.The VAP rate

extubation failure rate and mortality in the treatment group were significantly lower than those in the control group（P<0.01）.Conclusion The combo therapy of Shenfu Injection and MV is effective for AECOPD and it can shorten the invasive MV time and ICU stay time

increase the extubation success rate and reduce mortality.

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