Objective To evaluate the efficacy and safety of sweat pore-opening

network vessels-freeing and toxin-resolving therapy for plaque psoriasis.Methods Totally 150 cases of plaque psoriasis were randomized into the treatment group of 120 cases and control group of 30 cases.The treatment group was given sweat pore-opening formula and the control group was given blood-quickening toxin-resolving formula one dose daily for 8 weeks.The efficacy was evaluated.The scores of Psoriasis Area and Severity Index （PASI）

pruritus

skin lesions in different parts of the body and target lesions were observed before and after 2-week

4-week and 8-week treatment.Results The total effective rate of the treatment group and control group was 81.89% and 39.29% respectively

with a significant difference between groups （P<0.01）.There were significant differences between groups and within groups in the scores of PASI

pruritus and target lesions at different time points （P<0.05 or P<0.01）.There were significant differences between groups in the scores of PASI in head and upper limbs at different time points （P<0.01）.There were significant differences between groups and within groups in the scores of PASI in trunk and lower limbs at different time points （P<0.05）.There was no significant adverse reaction.Conclusion The sweat pore-opening

network vessels-freeing and toxin-resolving therapy is effective for plaque psoriasis.It can obviously relieve skin lesions and pruritus with a better safety.