Clinical Observation on Modified Liujunzi Decoction for 40 Cases of Functional Dyspepsia with Depression

WANG Yuliang; DANG Zhongqin; NIU Xueen; SUN Xiaona; ZHANG Yufeng; ZHANG Guangyu

doi:10.13288/j.11-2166/r.2013.17.014

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Clinical Observation on Modified Liujunzi Decoction for 40 Cases of Functional Dyspepsia with Depression

更新时间：2021-11-17

- Clinical Observation on Modified Liujunzi Decoction for 40 Cases of Functional Dyspepsia with Depression
- Journal of Traditional Chinese Medicine Vol. 54, Issue 17, Pages: 1480-1482(2013)
- 作者机构：
  
  河南省中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.17.014
  CLC： R259
- Published：2013
- 稿件说明：
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[1]王宇亮,党中勤,牛学恩,孙晓娜,张玉峰,张广玉.加味六君子汤治疗功能性消化不良伴抑郁症40例临床观察[J].中医杂志,2013,54(17):1480-1482.

WANG Yuliang, DANG Zhongqin, NIU Xueen, et al. Clinical Observation on Modified Liujunzi Decoction for 40 Cases of Functional Dyspepsia with Depression[J]. Journal of Traditional Chinese Medicine2013, 54(17): 1480-1482.
[1]王宇亮,党中勤,牛学恩,孙晓娜,张玉峰,张广玉.加味六君子汤治疗功能性消化不良伴抑郁症40例临床观察[J].中医杂志,2013,54(17):1480-1482. DOI： 10.13288/j.11-2166/r.2013.17.014.

WANG Yuliang, DANG Zhongqin, NIU Xueen, et al. Clinical Observation on Modified Liujunzi Decoction for 40 Cases of Functional Dyspepsia with Depression[J]. Journal of Traditional Chinese Medicine2013, 54(17): 1480-1482. DOI： 10.13288/j.11-2166/r.2013.17.014.

摘要

目的观察加味六君子汤治疗功能性消化不良伴抑郁症患者的临床疗效。方法将80例功能性消化不良伴抑郁症患者随机分为治疗组和对照组各40例

对照组给予多潘立酮片10mg

每日3次;圣约翰草提取物片300mg

每日3次。治疗组在对照组基础上给予加味六君子汤

每日1剂。两组均治疗30天后评价中医证候疗效

于治疗前后采用17项汉密尔顿量表（HAMD-17）评价抑郁程度

并检测胃动素（MOT）及促胃泌素（GAS）及胃排空率。结果两组中医证候疗效比较

治疗组总有效率（95.0%）明显高于对照组（87.5%）

差异有统计学意义（P<0.05）。治疗组HAMD-17积分改善、MOT、GAS及胃排空率均明显优于对照组

差异有统计学意义（P<0.05）。结论加味六君子汤能够显著改善功能性消化不良伴抑郁症患者的临床症状

升高MOT、GAS水平及胃排空率。

Abstract

Objective To observe the therapeutic effect of Modified Liujunzi Decoction for functional dyspepsia with depression.Methods Eighty cases of functional dyspepsia with depression were randomized into the treatment group and control group

with 40 in each.The control group was given domperidone tablets 10 mg each time

3 times daily and St.John’s wort extract tablets 300 mg each time

3 times daily.The treatment group was added with Modified Liujunzi Decoction one dose daily.Both groups were treated for 30 days.The total efficacy and the degrees of depression were evaluated.The motilin （MOT） and gastrin （GAS） was detected and the gastric emptying test was conducted.Results The total effective rate of TCM patterns in the treatment group and control group was 95.0% and 87.5% respectively

with a significant difference between groups （P<0.05）.Comparing with the control group

the scores of Hamilton Depression Rating Scale

the levels of MOT and GAS and the results of gastric emptying test in the treatment group were significantly improved （P<0.05）.Conclusion Modified Liujunzi Decoction can obviously relieve the symptoms of functional dyspepsia patients with depression.It can increase the levels of MOT and GAS and gastric emptying rate.

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