Objective To observe the therapeutic effect of wet compress of Compound Glycyrrhizin Solution for facial corticosteroid addictive dermatitis（FCAD）and its repairing effect on the barrier function of skin and stratum corneum.Methods Totally 150cases of FCAD were randomized into the treatment group and control group

with 90and 60in each.The treatment group was given wet compress of Compound Glycyrrhizin Solution with Non-woven mask paper 20min each time and twice daily.The control group was given tacrolimus ointment twice daily.The symptom scores were observed and recorded.The transepidermal water loss（TEWL）was detected by multi-function skin physiology analyzer.The thickness of stratum corneum was detected by confocal laser scanning microscopy before and after treatment.Results The symptom scores

TEWL and thickness of stratum corneum were significantly improved after 4-week and 8-week treatment and 4-week drug withdrawal in both groups（P<0.01）.Comparing with the treatment group

the symptom scores in the control group were significantly decreased after 4-week and 8-week treatment（P<0.01）.The symptom scores in the treatment group were significantly lower than those in the control group after 4-week drug withdrawal（P<0.01）.The TEWL was significantly decreased in both groups after 4-week and 8-week treatment

especially in the treatment group after 4-week treatment（P<0.01）and after 4week drug withdrawal（P<0.01）.Comparing with the control group

the stratum corneum was significantly thicker in the treatment group after 4-week drug withdrawal（P<0.01）.The total effective rate of the control group was significantly higher than that of the treatment group after 4-week and 8-week treatment（P<0.05）.The total effective rate of the treatment group was significantly higher than that of the control group after 4-week drug withdrawal（P<0.05）.Conclusion The wet compress of Compound Glycyrrhizin Solution is effective for FCAD.It can repair the skin barrier function and recover the stratum corneum.