Objective To study the mechanism of Curcumin for acute pulmonary embolism（APE）.Methods The APE models were established by self-embolism.Totally 72SD rats were randomized into the normal group

sham operation group

model group and Curcumin group

with 18in each.The Curcumin group was gavaged with 100mg/kg Curcumin one day and 40min before operation

and at the 6th

24th and 72th hour after modeling respectively.Another three groups were gavaged with normal saline at the same time points.The lung tissue and serum was taken from 6rats at the 6th

24th and 72th hour after modeling.The extracellular signal-regulated protein kinase（ERK）

phosphoinositide 3-kinase（PI3K）and protein kinase B（Akt）was detected by Western Blot.The serum levels of brain natriuretic peptide（BNP）

troponin T（TnT）and D-dimer were detected by ELISA.Results There were significant differences between the normal group

model group and Curcumin group in ERK

PI3Kand Akt at the same time point（P<0.01）.There was no significant difference between the model group and Curcumin group in ERK at the 24th hour after modeling（P>0.05）.Comparing with the model group

ERK

PI3Kand Akt in the lung tissue was significantly decreased in other groups at the same time point（P<0.01）.Comparing with the normal group

the levels of BNP

TnT and D-Dimer were significantly increased in the model group at the same time point（P<0.01）.Comparing with the model group

the levels of BNP

TnT and D-Dimer were significantly decreased in the Curcumin group at the same time point（P<0.05or P<0.01）.Conclusion Curcumin can decrease ERK

PI3Kand Akt in the lung tissue and serum levels of BNP

TnT and D-Dimer.It might be one of the mechanisms to explain why curcumin can improve the prognosis of APE.