Clinical Study on Kidney-Supplementing Blood-Quickening Medicinal Combined with Western Medicine for 100 Cases of Senile Osteoporosis

ZHANG Xiaojun; NIE Jing; XIONG Jingfang; WANG Qingping; SUN Wenli

doi:10.13288/j.11-2166/r.2013.18.028

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Clinical Study on Kidney-Supplementing Blood-Quickening Medicinal Combined with Western Medicine for 100 Cases of Senile Osteoporosis

更新时间：2021-11-17

- Clinical Study on Kidney-Supplementing Blood-Quickening Medicinal Combined with Western Medicine for 100 Cases of Senile Osteoporosis
- Journal of Traditional Chinese Medicine Vol. 54, Issue 18, Pages: 1562-1565(2013)
- 作者机构：
  
  杭州市红十字会医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.18.028
  CLC： R580
- Published：2013
- 稿件说明：
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[1]张晓君,聂晶,熊静芳,王青平,孙文丽.补肾活血中药联合补钙剂治疗老年骨质疏松症100例临床研究[J].中医杂志,2013,54(18):1562-1565.

ZHANG Xiaojun, NIE Jing, XIONG Jingfang, et al. Clinical Study on Kidney-Supplementing Blood-Quickening Medicinal Combined with Western Medicine for 100 Cases of Senile Osteoporosis[J]. Journal of Traditional Chinese Medicine2013, 54(18): 1562-1565.
[1]张晓君,聂晶,熊静芳,王青平,孙文丽.补肾活血中药联合补钙剂治疗老年骨质疏松症100例临床研究[J].中医杂志,2013,54(18):1562-1565. DOI： 10.13288/j.11-2166/r.2013.18.028.

ZHANG Xiaojun, NIE Jing, XIONG Jingfang, et al. Clinical Study on Kidney-Supplementing Blood-Quickening Medicinal Combined with Western Medicine for 100 Cases of Senile Osteoporosis[J]. Journal of Traditional Chinese Medicine2013, 54(18): 1562-1565. DOI： 10.13288/j.11-2166/r.2013.18.028.

摘要

目的评价补肾活血中药联合补钙剂治疗老年男性骨质疏松症（OP）的疗效及其可能作用机制。方法将老年男性OP患者200例随机分为治疗组和对照组各100例。在口服钙尔奇D基础上治疗组给予补肾活血胶囊

对照组给予阿仑膦酸钠片口服治疗

疗程为1年

随访6个月。观察两组治疗前后不同时间及随访时疼痛积分

检测腰椎（L2-4）、左髋部骨密度（BMD）及血清Ⅰ型前胶原氨基端前肽（PINP）、β-Ⅰ型胶原羧基端肽（β-CTX）

检测空腹血清白细胞介素6（IL-6）、白细胞介素1β（IL-1β）、胰岛素样生长因子1（IGF-1）。结果治疗后6个月、1年及随访6个月时两组患者疼痛积分较治疗前均明显改善（P<0.05或P<0.01）

治疗后1年及随访6个月时治疗组疼痛积分低于对照组（P<0.05）。治疗1年后两组腰椎、左髋部BMD较治疗前均提高（P<0.05）。治疗组治疗后1年及随访6个月时PINP、β-CTX均明显改善

且优于对照组（P<0.05或P<0.01）。治疗后1年两组IL-1β、IL-6降低

IGF-1升高（P<0.05或P<0.01）

治疗组IL-6、IGF-1改善更显著（P<0.05）。结论补肾活血中药联合补钙剂能改善老年男性OP患者骨痛症状

调节IL-1β、IL-6、IGF-1水平

改善骨转换

提高骨密度。

Abstract

Objective To evaluate the efficacy of kidney-supplementing blood-quickening medicinal for senile osteoporosis and its intervention effect on interleukin-1β（IL-1β）

IL-6and insulin-like growth factor-1（IGF-1）and study on its possible mechanism.Methods Two hundred male patients with senile osteoporosis were randomized into the treatment group and control group

with 100in each.The treatment group was given kidney-supplementing blood-quickening capsule.The control group was given Alendronate Sodium Tablets.Both groups were also given Caltrate D.All the patients were treated for 1year and followed up for 6months.The pain integration was observed.The dual-energy X-ray absorptiometry was used to detect the bone mineral density（BMD）of lumbar spine（L2-4）and left hip.The serum procollagen type I N-terminal propeptide（PINP） andβ-I collagen C-terminal peptide（β-CTX）was detected by electrochemiluminescence immunoassay.The serum levels of IL-6

IL-1βand IGF-1 were detected by enzyme-linked immunosorbent assay.Adverse reactions were monitored in both groups.Results The pain integrations were significantly improved in both groups after 6-month and 1-year treatment and 6month follow-up（P<0.05or P<0.01）.The pain integrations in the treatment group were significantly lower than those in the control group after 1-year treatment and 6-month follow-up（P<0.05）.The BMD of lumbar spine（L2-4）and left hip was significantly increased in both groups after 1-year treatment（P<0.05）.The PINP andβ-CTX was significantly improved in the treatment group after 1-year treatment and 6-month follow-up（P<0.05or P<0.01）

with a significant difference between groups（P<0.05）.The levels of IL-6and IL-1βwere significantly decreased but IGF-1level was significantly increased in both groups after 1-year treatment（P<0.05or P<0.01）

especially IL-6and IGF-1in the treatment group（P<0.05）.Conclusion Kidney-supplementing blood-quickening medicinal can relieve bone pain of osteoporosis in the aging male

regulate the levels of IL-1β

IL-6and IGF-1

improve bone turnover and increase bone density without obvious adverse reaction.

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Related Institution

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Heilongjiang University of Chinese Medicine

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