Objective To explore the action mechanism of Liuwei Dihuang Pill（Six-Ingredient Rehmannia Pill）for type 2 diabetic patients with kidney yin deficiency pattern.Methods Totally 133type 2diabetic patients with kidney yin deficiency pattern were randomized into the treatment group of 91cases and control group of 42cases.Both groups were given basic treatment including diet control

body weight control

exercise and oral hypoglycemic drugs.The treatment group was added with Liuwei Dihuang Pill

10pills once and 3times daily for 12weeks.The levels of adiponectin

high-sensitivity C-reactive protein（hs-CRP）

fasting blood glucose（FBG）

HbA1c

triglyceride（TG）

low-density lipoprotein cholesterol（LDL-C）and serum creatinine（SCr）were detected before and after treatment.Results The level of HbA1c

FBG and TG was significantly decreased in the control group after treatment（P<0.05or P<0.01）.The level of hs-CRP

SCr

HbA1c

FBG

TG and LDL-C were significantly decreased but adiponectin was significantly increased in the treatment group after treatment（P<0.05 or P<0.01）.Comparing with the control group

the level of hs-CRP

HbA1c

FBG and TG was significantly decreased but adiponectin was significantly increased in the treatment group after treatment（P<0.05）.Conclusion Liuwei Dihuang Pill can obviously increase the levels of serum adiponectin and reduce the levels of hs-CRP

FBG

TG and LDL-C in diabetic patients with kidney yin deficiency pattern.