Effect of Shangke Jiegu Tablets on the Expression of Cyclooxygenase-2 in Bone Tissue of Rabbit with Mandibular Defect

WENG Chunhui; YU Suihua; LIN Shan; DAI Libing; ZHONG Zhiyong

doi:10.13288/j.11-2166/r.2013.22.021

您当前的位置：

首页 >

文章列表页 >

Effect of Shangke Jiegu Tablets on the Expression of Cyclooxygenase-2 in Bone Tissue of Rabbit with Mandibular Defect

更新时间：2021-11-17

- Effect of Shangke Jiegu Tablets on the Expression of Cyclooxygenase-2 in Bone Tissue of Rabbit with Mandibular Defect
- Journal of Traditional Chinese Medicine Vol. 54, Issue 22, Pages: 1949-1952(2013)
- 作者机构：
  
  1. 暨南大学医学院第四附属医院/广州市红十字会医院
  2. 广州市创伤外科研究所
  3. 广东省医学实验动物中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.22.021
  CLC： R285.5
- Published：2013
- 稿件说明：
移动端阅览
[1]翁春辉,余穗华,林珊,戴丽冰,钟志勇.伤科接骨片对兔下颌骨缺损骨组织环氧合酶-2表达的影响[J].中医杂志,2013,54(22):1949-1952.

WENG Chunhui, YU Suihua, LIN Shan, et al. Effect of Shangke Jiegu Tablets on the Expression of Cyclooxygenase-2 in Bone Tissue of Rabbit with Mandibular Defect[J]. Journal of Traditional Chinese Medicine2013, 54(22): 1949-1952.
[1]翁春辉,余穗华,林珊,戴丽冰,钟志勇.伤科接骨片对兔下颌骨缺损骨组织环氧合酶-2表达的影响[J].中医杂志,2013,54(22):1949-1952. DOI： 10.13288/j.11-2166/r.2013.22.021.

WENG Chunhui, YU Suihua, LIN Shan, et al. Effect of Shangke Jiegu Tablets on the Expression of Cyclooxygenase-2 in Bone Tissue of Rabbit with Mandibular Defect[J]. Journal of Traditional Chinese Medicine2013, 54(22): 1949-1952. DOI： 10.13288/j.11-2166/r.2013.22.021.

摘要

目的探讨伤科接骨片促兔下颌骨缺损骨组织修复的可能作用机制。方法健康雄性新西兰兔72只

随机分为正常对照组（24只）、模型对照组（24只）和伤科接骨片组（24只）

除正常对照组外其余各组建立下颌骨缺损模型。正常对照组、模型对照组给予正常饲料40g/d

伤科接骨片组给予伤科接骨片饲料40g/d（约含伤科接骨片0.528g）。分别于造模后第7、14、28、56天各处死6只兔

行下颌骨侧位X线片检查后

收集下颌骨缺损处骨组织块

检测环氧合酶-2（COX-2）蛋白、COX-2mRNA表达。结果与正常对照组比较

模型对照组造模后第14、28天兔下颌骨组织COX-2蛋白及COX-2mRNA表达明显升高（P<0.05）;与模型对照组比较

伤科接骨片组造模后第14、28、56天兔下颌骨组织COX-2蛋白及COX-2mRNA表达明显升高（P<0.05）。影像学显示

伤科接骨片组较模型对照组兔下颌骨缺损区成骨速度更快

新生骨密度更大。结论伤科接骨片可能通过上调COX-2蛋白及COX-2mRNA表达促进兔下颌骨缺损骨组织的修复。

Abstract

Objective To study the possible repair mechanism of Shangke Jiegu Tablets（bone-setting tablets）for mandibular defect.Methods Totally 72healthy male New Zealand rabbits were randomized into the normal control group

model control group and Shangke Jiegu Tablets group

with 24in each.The mandibular defect models were established in all groups except the normal control group.The normal control group and model control group were given 40g/d normal forage.The Shangke Jiegu Tablets group was given 40g/d Shangke Jiegu Tablets forage（containing about 0.528g Shangke Jiegu Tablets）.Six rabbits in each group were sacrificed on the 7th

14th

28th and 56th day after modeling respectively.The bone tissue in mandibular defect area was collected after mandible X-ray examination.The protein and mRNA expression of Cyclooxygenase-2（COX-2）and the positive dyeing strength and area of bone tissue were detected.Results Comparing with the normal control group

the protein and mRNA expression of COX-2increased significantly on the 14th and 28th day after modeling in the model control group（P<0.05）.Comparing with the model control group

the protein and mRNA expression of COX-2increased significantly on the 14th

28th and 56th day after modeling in the Shangke Jiegu Tablets group（P<0.05）.Imageology showed that the speed of bone-formation was faster and the density of new bone was greater in mandibular defect area in the Shangke Jiegu Tablets group.Conclusion Shangke Jiegu Tablets can repair the mandibular defect by up-regulating the protein and mRNA expression of COX-2.

关键词

Keywords

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Effect of Xiaoqinglong Decoction （小青龙汤） on Th2 Immune Responses and Nasal Mucosal TSLP/OX40L Pathway in Allergic Rhinitis Model Rats

Construction and Application of a Real-World Cohort of Community-Acquired Pneumonia Based on a Multimodal Large-Scale Traditional Chinese Medicine Big Data Platform

Differentiation and Treatment of Small Cell Lung Cancer from the Perspective of "Internal Wind in Hidden Circulation"

LI Guolie's Experience in Treating Orthostatic Hypotension from the Perspective of "Raising the Clear and Directing the Turbid Downward"

Related Author

No data

Related Institution

No data

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰