A Multicentered,Randomize-Controlled Trial of Integrative Medicine for Acute-on-Chronic（Subacute）Liver Failure

WANG Lifu; LI Jun; LI Fengyi; ZHANG Xiaofeng; ZHANG Mingxiang; CAO Wukui; LI Qin; WEN Xianmin; MAO Dewen; SUN Kewei; ZHOU Xiaozhou; TIAN Deying; GUO Jianchun; YANG Daguo; LI Xiuhui; YANG Hongzhi; WANG Xianbo; ZHUO Yunhui; ZHANG Qin; LI Hanmin; HU Xiaoyu; ZHAO Wei; ZHANG Fuchun; HE Liyun

doi:10.13288/j.11-2166/r.2013.22.026

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A Multicentered,Randomize-Controlled Trial of Integrative Medicine for Acute-on-Chronic（Subacute）Liver Failure

更新时间：2021-11-17

- A Multicentered,Randomize-Controlled Trial of Integrative Medicine for Acute-on-Chronic（Subacute）Liver Failure
- Journal of Traditional Chinese Medicine Vol. 54, Issue 22, Pages: 1922-1925(2013)
- 作者机构：
  
  1. 中国人民解放军第三○二医院
  2. 深圳市第三人民医院
  3. 中国中医科学院中医临床基础医学研究所
  4. 沈阳市第六人民医院
  5. 首都医科大学附属北京佑安医院
  6. 天津市传染病医院
  7. 中山大学附属第三医院
  8. 福州市传染病医院
  9. 首都医科大学附属北京地坛医院
  10. 成都市传染病医院
  11. 上海中医药大学附属曙光医院
  12. 广西中医学院第一附属医院
  13. 上海公共卫生临床中心
  14. 湖南中医药大学第一附属医院
  15. 湖北省中医院
  16. 深圳市中医院
  17. 成都中医药大学附属医院
  18. 华中科技大学同济医学院附属同济医院
  19. 南京市第二医院
  20. 杭州市第六人民医院
  21. 广州市第八人民医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.22.026
  CLC： R575.3
- Published：2013
- 稿件说明：
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[1]王立福,李筠,李丰衣,张晓峰,张明香,曹武奎,李芹,温贤敏,毛德文,孙克伟,周小舟,田德英,过建春,杨大国,李秀惠,杨宏志,王宪波,卓蕴慧,张琴,李瀚旻,扈晓宇,赵伟,张复春,何丽云.中医辨证联合西药治疗慢加急性(亚急性)肝衰竭多中心随机对照研究[J].中医杂志,2013,54(22):1922-1925.

WANG Lifu, LI Jun, LI Fengyi, et al. A Multicentered,Randomize-Controlled Trial of Integrative Medicine for Acute-on-Chronic（Subacute）Liver Failure[J]. Journal of Traditional Chinese Medicine2013, 54(22): 1922-1925.
[1]王立福,李筠,李丰衣,张晓峰,张明香,曹武奎,李芹,温贤敏,毛德文,孙克伟,周小舟,田德英,过建春,杨大国,李秀惠,杨宏志,王宪波,卓蕴慧,张琴,李瀚旻,扈晓宇,赵伟,张复春,何丽云.中医辨证联合西药治疗慢加急性(亚急性)肝衰竭多中心随机对照研究[J].中医杂志,2013,54(22):1922-1925. DOI： 10.13288/j.11-2166/r.2013.22.026.

WANG Lifu, LI Jun, LI Fengyi, et al. A Multicentered,Randomize-Controlled Trial of Integrative Medicine for Acute-on-Chronic（Subacute）Liver Failure[J]. Journal of Traditional Chinese Medicine2013, 54(22): 1922-1925. DOI： 10.13288/j.11-2166/r.2013.22.026.

摘要

目的观察中西医结合治疗方案对慢加急性（亚急性）肝衰竭患者病死率的影响。方法将来自20个中心的511例患者随机分为治疗组（给予基础治疗+中医药辨证治疗+对症支持治疗）360例与对照组（给予基础治疗+对症支持治疗）151例

两组均治疗8周

随访至第48周。治疗后判定两组临床疗效

并于治疗后第8、12、24、48周观察两组的病死率。结果治疗组治疗第8、12、24、48周病死率分别为20.99%、22.61%、23.06%、25.99%

对照组分别为30.87%、32.21%、34.23%、34.23%

治疗组各时间点病死率均低于对照组（P<0.05）。治疗组临床疗效总有效率67.23%

对照组总有效率54.36%

两组比较差异有统计学意义（P<0.05）。结论中医辨证联合西药治疗可降低慢加急性（亚急性）肝衰竭患者病死率

提高临床疗效。

Abstract

Objective To observe the effect of integrative medicine on the mortalit in patients with acute-on-chronic（subacute）liver failure.Methods A prospective

multicenter and randomized controlled study was conducted to randomize511patients into the treatment group（basic therapy+ TCM treatment+symptomatic and supportive treatment）and control group（basic therapy + symptomatic and supportive treatment）

with 360and 151in each.Both groups were treated for 8weeks and followed up to the 48th week.The mortality rate and survival time was observed in the 8th

12th

24th and 48th week after treatment.The therapeutic effect was evaluated in the 48th week.Results The mortality in the 8th

12th

24th and 48th week after treatment were 20.99%

22.61%

23.06%

and 25.99%in the treatment group

and 30.87%

32.21%

34.23%

and 34.23%in the control group

respectively

with significant differences between groups（P<0.05）.The survival rate in the treatment group was significantly higher than that in the control group（P<0.01）.The total effective rate of the treatment group and control group was 67.23% and 54.36% respectively

with a significant difference between groups（P<0.05）.Conclusion The integrative medicine is effective for acute-on-chronic（subacute）liver failure with a low mortality rate and better efficacy.

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