Objective To observe the therapeutic effect of Shenning Formula（Tranquilizing Formula） combined with western medicine for patients recovering from acute cerebral infarction complicated with mild to moderate depression（ACID）.Methods Totally 120 ACID patients were randomized into the treatment group and control group

with 60 in each.Both groups were orally given enteric-coated aspirin tablets and sertraline hydrochloride.The treatment group was added with one dose of Shenning Formula daily.The treatment lasted for 30 days.The therapeutic effect was evaluated with Hamilton Depression Rating Scale（HAMD）

National Institutes of Health Stroke Scale（NIHSS）

Modified Rankin Scale（mRS）

and Barthel Index（BI）.Results After treatment

the HAMD scores ranging from 8 to 16 points before treatment were significantly decreased in the treatment group and lower than those in the control group（P<0.01）.After treatment

the HAMD scores ranging from 17 to 23 points before treatment were significantly decreased in both groups（P<0.01）

and 4 factor scores of depression

easy to wake up

early awakening

and gastrointestinal symptoms in the treatment group were significantly lower than those in the control group（P<0.05or P<0.01）.The average dose of sertraline in the treatment group was significantly decreased after treatment and lower than that in the control group（P<0.01）.After treatment

the number of patients whose NIHSS score improvement greater than or equal to 40%

mRS rating from 0 to 2

and BI score greater than or equal to 85 points in the treatment group was more than that in the control group（all P<0.05）.Conclusion Integrative medicine can relieve the depressive symptoms

reduce daily average dose of sertraline

promote recovery of neurological function

reduce disability rating

and improve daily living skills of ACID patients.