Clinical Observation on Xiegan Anshen Formula for 100 Cases of Generalized Anxiety Disorder

XIONG Hang; GUO Rongjuan; WANG Yulai; WANG Gesheng

doi:10.13288/j.11-2166/r.2014.01.011

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Clinical Observation on Xiegan Anshen Formula for 100 Cases of Generalized Anxiety Disorder

更新时间：2021-11-17

- Clinical Observation on Xiegan Anshen Formula for 100 Cases of Generalized Anxiety Disorder
- Journal of Traditional Chinese Medicine Vol. 55, Issue 1, Pages: 42-44(2014)
- 作者机构：
  
  1. 北京中医药大学
  2. 北京中医药大学东方医院
  3. 澳门科技大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.01.011
  CLC： R277.7
- Published：2014
- 稿件说明：
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[1]熊航,郭蓉娟,王玉来,王革生.泻肝安神方治疗广泛性焦虑症患者100例临床观察[J].中医杂志,2014,55(01):42-44.

XIONG Hang, GUO Rongjuan, WANG Yulai, et al. Clinical Observation on Xiegan Anshen Formula for 100 Cases of Generalized Anxiety Disorder[J]. Journal of Traditional Chinese Medicine2014, 55(1): 42-44.
[1]熊航,郭蓉娟,王玉来,王革生.泻肝安神方治疗广泛性焦虑症患者100例临床观察[J].中医杂志,2014,55(01):42-44. DOI： 10.13288/j.11-2166/r.2014.01.011.

XIONG Hang, GUO Rongjuan, WANG Yulai, et al. Clinical Observation on Xiegan Anshen Formula for 100 Cases of Generalized Anxiety Disorder[J]. Journal of Traditional Chinese Medicine2014, 55(1): 42-44. DOI： 10.13288/j.11-2166/r.2014.01.011.

摘要

目的观察泻肝安神方治疗广泛性焦虑症（GAD）的临床疗效。方法将130例GAD患者按照3∶1比例随机分配到治疗组100例和对照组30例

治疗组给予泻肝安神方颗粒

每日1次

每次12 g;对照组给予帕罗西汀片

每日1次

每次10或20mg

两组患者均治疗6周后观察临床疗效。两组分别于治疗前、治疗后第2、4、6周进行汉密尔顿焦虑量表（HAMA）评分

治疗后第2、4、6周进行副反应量表（TESS）评分。结果两组患者HAMA评分治疗第2、4、6周后与本组治疗前比较

差异均有统计学意义（P<0.05）。治疗组临床疗效总有效率为94.0%

对照组为93.3%

两组总有效率比较差异无统计学意义（P>0.05）。治疗组患者治疗2、4、6周后TESS评分低于对照组

差异均有统计学意义（P<0.05或P<0.01）。结论泻肝安神方治疗GAD与帕罗西汀片疗效相当

但泻肝安神方不良反应少、程度较轻。

Abstract

To observe the therapeutic effect of Xiegan Anshen Formula（ Liver-Draining Spirit- Quieting Formula） on generalized anxiety disorder（ GAD）. Methods Totally 130 cases of GAD were randomized into the treatment group of 100 cases and control group of 30 cases. The treatment group was given 12 g granules of Xiegan Anshen Formula once daily. The control group was given 10 mg paroxetine tablet once daily. The treatment lasted for 6 weeks. For both groups

Hamilton Anxiety Scale（ HAMA） scores were treated before treatment and 2

6 weeks after treatment

and Treatment Emergent Symptom Scale（ TESS） scores were recorded 2

6 weeks after treatment. Results There were significant differences between before and after 2-week

4-week and 6-week treat- ment in the scores of HAMA in both groups（ P < 0. 01）. No significant difference was found between both groups after treatment. The total effective rate of the treatment group and control group was 94. 0% and 93. 3% respectively

with no significant difference between groups（ P > 0. 05）. The scores of TESS in the treatment group in the 2nd

4th and 6th week of treatment was significantly lower than those in the control group（ P < 0. 05 or P < 0. 01）. Conclusion Xiegan Anshen Formula is effective for GAD with an equivalent efficacy and less side reaction as compared with paroxetine.

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