Objective To observe the preventive and therapeutic effect of Huangqin（ Radix Scutellariae

黄芩） Mouthwashes on oral fungal infection in active systemic lupus erythematosus（ SLE） patients who received glucocorticoid therapy. Methods Ninety active SLE patients who received glucocorticoid therapy were randomized into the mouthwashes group

soda water group and control group

with 30 in each. Three groups were given mouthwashes with Huangqin Mouthwashes

2. 5% sodium bicarbonate

and normal saline respectively after three meals while received glucocorticoid therapy. The incidence of oral fungal infection was observed during treatment. The days of fungal infection and its healing days were recorded. Results The incidence of oral fungal infection was 6. 7%

13. 3% and 36. 7% in the mouthwashes group

soda water group and control group respectively. Comparing with the control group

the incidence of oral fungal infection in the mouthwashes group and soda group was significantly decreased（ P <0. 05）. Comparing with the control group

the occurance of fungal infection was later and the healing time was shorter in the mouthwashes group and soda water group（ P < 0. 05）

especially in the mouthwashes group（ P < 0. 05）. Conclusion Huangqin Mouthwashes is effective in preventing and treating oral fungal infection in active SLE patients who received glucocorticoid therapy.