Effects of Astragaloside and Salvianolateon A on TGF-β1 mRNA and CTGF mRNA in Renal Tissue of Chronic Renal Failure Rats

TANG Ying; ZHU Yi; WANG Dong; HE Liqun

doi:10.13288/j.11-2166/r.2014.02.015

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Effects of Astragaloside and Salvianolateon A on TGF-β1 mRNA and CTGF mRNA in Renal Tissue of Chronic Renal Failure Rats

更新时间：2021-11-17

- Effects of Astragaloside and Salvianolateon A on TGF-β1 mRNA and CTGF mRNA in Renal Tissue of Chronic Renal Failure Rats
- Journal of Traditional Chinese Medicine Vol. 55, Issue 2, Pages: 144-147(2014)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院
  2. 上海中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.02.015
  CLC： R285.5
- Published：2014
- 稿件说明：
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[1]唐英,朱祎,王东,何立群.黄芪、丹参有效单体对慢性肾功能衰竭大鼠肾组织转化生长因子β1和结缔组织生长因子mRNA的影响[J].中医杂志,2014,55(02):144-147.

TANG Ying, ZHU Yi, WANG Dong, et al. Effects of Astragaloside and Salvianolateon A on TGF-β1 mRNA and CTGF mRNA in Renal Tissue of Chronic Renal Failure Rats[J]. Journal of Traditional Chinese Medicine2014, 55(2): 144-147.
[1]唐英,朱祎,王东,何立群.黄芪、丹参有效单体对慢性肾功能衰竭大鼠肾组织转化生长因子β1和结缔组织生长因子mRNA的影响[J].中医杂志,2014,55(02):144-147. DOI： 10.13288/j.11-2166/r.2014.02.015.

TANG Ying, ZHU Yi, WANG Dong, et al. Effects of Astragaloside and Salvianolateon A on TGF-β1 mRNA and CTGF mRNA in Renal Tissue of Chronic Renal Failure Rats[J]. Journal of Traditional Chinese Medicine2014, 55(2): 144-147. DOI： 10.13288/j.11-2166/r.2014.02.015.

摘要

目的探讨黄芪、丹参有效单体黄芪甲苷和丹参多酚酸A干预慢性肾功能衰竭（CRF）的可能作用机制。方法 40只SD大鼠通过5/6肾切除建立CRF动物模型

根据血肌酐（Cr）值随机分为模型组、黄芪甲苷组、丹参多酚酸A组及科素亚组各10只

并设正常组10只。黄芪甲苷组给予黄芪甲苷1.4mg/（kg·d）

丹参多酚酸A组给予丹参多酚酸A 17.1mg/（kg·d）

科素亚组给予科素亚8.6mg/（kg·d）灌胃

模型组和正常组予等量蒸馏水灌胃。8周后测定各组大鼠血清Cr、尿素氮（BUN）水平

并检测肾组织转化生长因子β1（TGF-β1）mRNA及结缔组织生长因子（CTGF）mRNA的表达。结果黄芪甲苷组、丹参多酚酸A组血清Cr、BUN较模型组显著降低（P<0.01）。黄芪甲苷组、丹参多酚酸A组、科素亚组肾组织TGF-β1、CTGF mRNA较模型组亦降低（P<0.05或P<0.01）。丹参多酚酸A组在降低BUN、Cr方面优于科素亚组（P<0.05或P<0.01）。结论黄芪甲苷、丹参多酚酸A可能通过抑制肾组织TGF-β1、CTGF mRNA的表达

降低血清Cr、BUN水平

从而延缓CRF肾功能衰竭的恶化。

Abstract

Objective To research the possible mechanism of Astragaloside and Salvianolateon A for chronic renal failure（ CRF）. Methods The CRF models were established by 5 /6 nephrectomy in Sprague Dawley（ SD） rats. The rat models were randomized into the model group

Astragaloside group

Salvianolateon A group and Cozaar group according to the serum creatinine（ SCr） value

with 10 in each. Another 10 rats were selected as the normal group. The Astragaloside group

Salvianolateon A group and Cozaar group was gavaged with 1. 4 mg /（ kg·d） Astragaloside

17. 1 mg /（ kg·d） Salvianolateon A and 8. 6 mg /（ kg·d） Cozaar respectively. The model group and normal group were gavaged with the same amount of distilled water. The levels of SCr and blood urea nitrogen（ BUN） were detected 8 weeks later. The expressions of transforming growth factor-β1（ TGF-β1） and connective tissue growth factor（ CTGF） mRNA were detected. Results Comparing with the model group

the levels of SCr and BUN in the Astragaloside group and Salvianolateon A group were significantly decreased（ P < 0. 01）. Comparing with the model group

the expressions of TGF-β1 and CTGF mRNA in the Astragaloside group

Salvianolateon A group and Cozaar group were significantly decreased（ P < 0. 05 or P < 0. 01）. The Salvianolateon A group was superior to the Cozaar group in decreasing BUN and SCr（ P < 0. 05 or P < 0. 01）. Conclusion Astragaloside and Salvianolateon A can slow the progression of renal failure probably by inhibiting the expressions of TGF-β1 and CTGF mRNA and decreasing the levels of SCr and BUN.

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