Effects of Buzhong Yiqi Decoction on Inflammation and Granulation Tissue Proliferation of Incision in Rats With Spleen Qi Deficiency Pattern

FAN Huijie; CHAI Zhi; YAN Runhong; LI Yanyan; ZHOU Ran

doi:10.13288/j.11-2166/r.2014.03.016

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Effects of Buzhong Yiqi Decoction on Inflammation and Granulation Tissue Proliferation of Incision in Rats With Spleen Qi Deficiency Pattern

更新时间：2021-11-17

- Effects of Buzhong Yiqi Decoction on Inflammation and Granulation Tissue Proliferation of Incision in Rats With Spleen Qi Deficiency Pattern
- Journal of Traditional Chinese Medicine Vol. 55, Issue 3, Pages: 238-241(2014)
- 作者机构：
  
  1. 山西中医学院基础医学院
  2. 山西中医学院第二中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.03.016
  CLC： R285.5
- Published：2014
- 稿件说明：
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[1]樊慧杰,柴智,闫润红,李艳彦,周然.补中益气汤对脾气虚证模型大鼠手术切口肌肉组织炎症反应和肉芽组织增生的影响[J].中医杂志,2014,55(03):238-241.

FAN Huijie, CHAI Zhi, YAN Runhong, et al. Effects of Buzhong Yiqi Decoction on Inflammation and Granulation Tissue Proliferation of Incision in Rats With Spleen Qi Deficiency Pattern[J]. Journal of Traditional Chinese Medicine2014, 55(3): 238-241.
[1]樊慧杰,柴智,闫润红,李艳彦,周然.补中益气汤对脾气虚证模型大鼠手术切口肌肉组织炎症反应和肉芽组织增生的影响[J].中医杂志,2014,55(03):238-241. DOI： 10.13288/j.11-2166/r.2014.03.016.

FAN Huijie, CHAI Zhi, YAN Runhong, et al. Effects of Buzhong Yiqi Decoction on Inflammation and Granulation Tissue Proliferation of Incision in Rats With Spleen Qi Deficiency Pattern[J]. Journal of Traditional Chinese Medicine2014, 55(3): 238-241. DOI： 10.13288/j.11-2166/r.2014.03.016.

摘要

目的观察补中益气汤对脾气虚证大鼠手术切口愈合的影响。方法将60只SD大鼠随机分为正常组、脾气虚模型组、补中益气汤组

每组20只。除正常组外其余各组采用苦寒泻下法制备脾气虚动物模型

各组造模第19d于背部做长约4cm并平行脊柱的切口

补中益气汤组手术当天大鼠每日灌服7g/kg的补中益气汤水煎剂;脾气虚模型组和正常组大鼠每日给予等体积蒸馏水灌胃。各组分别于术后3d、7d各处死10只大鼠

取距手术切口两侧肌肉组织行HE染色

光镜下观察手术切口处炎症反应和肉芽组织增生情况

高倍镜下对切口肌肉组织成纤维细胞进行计数。结果补中益气汤组术后7d切口处可见新生肉芽组织

其间有大量新生血管

并有巨噬细胞、淋巴细胞浸润。与正常组术后3d、7d比较

脾气虚模型组成纤维细胞数量显著降低（P<0.01）;与模型组术后3d、7d比较

补中益气汤组术后同时间点的成纤维细胞数量显著升高（P<0.05或P<0.01）。结论补中益气汤通过改善手术切口局部肌肉组织炎症反应和肉芽组织增生情况

可促进切口愈合。

Abstract

Objective To observe the effect of Buzhong Yiqi Decoction（ Center-Supplementing Qi-Boosting Decoction

补中益气汤） on incision healing in rats with spleen qi deficiency pattern.Methods Sixty SD rats were randomized into the normal group

model group and Buzhong Yiqi Decoction group

with 20 in each.The rat models of spleen qi deficiency pattern were established in the model group and Buzhong Yiqi Decoction group.A 4 cm incision paralleled to the spine was made on the back of rats in the each of groups on the 19th day of modeling.The Buzhong Yiqi Decoction group was gavaged with 7g / kg of Buzhong Yiqi Decoction daily after operation.The normal group and model group were gavaged with an equal volume of distilled water.Ten rats were sacrificed respectively on the 3rd day and 7th day after operation in each group.The muscle tissue on both sides of surgical incision was sampled and dyed with routine HE staining.The inflammation and granulation tissue formation was observed.The fibroblast cells were counted.Results The new granulation tissue with new blood vessels

macrophages and lymphocytes could be seen in the Buzhong Yiqi Decoction group 7 days after operation.Comparing with the normal group

the number of fibroblasts was significantly decreased in the model group 3 days and 7 days after operation（ P <0.01）.Comparing with the model group

the number of fibroblasts was significantly increased in the Buzhong Yiqi Decoction group 3 days and 7 days after operation（ P < 0.05 or P < 0.01）.Conclusion Buzhong Yiqi Decoction can promote incision healing by relieving inflammation and granulation tissue formation of muscle tissue.

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