A Clinical Observation on Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula for 40 Patients with Precancerous Lesions of Chronic Atrophic Gastritis

BAI Yuning; WANG Shaoli; YAO Naili; LIU Ping; ZHU Yuling; MA Jizheng; PENG Yan

doi:10.13288/j.11-2166/r.2014.04.010

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A Clinical Observation on Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula for 40 Patients with Precancerous Lesions of Chronic Atrophic Gastritis

更新时间：2021-11-17

- A Clinical Observation on Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula for 40 Patients with Precancerous Lesions of Chronic Atrophic Gastritis
- Journal of Traditional Chinese Medicine Vol. 55, Issue 4, Pages: 301-304(2014)
- 作者机构：
  
  1. 中国中医科学院广安门医院
  2. 北京大学第一医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.04.010
  CLC： R259
- Published：2014
- 稿件说明：
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[1]白宇宁,王少丽,姚乃礼,柳平,朱昱翎,马继征,彭艳.健脾通络解毒方加减辨治慢性萎缩性胃炎癌前病变40例临床观察[J].中医杂志,2014,55(04):301-304.

BAI Yuning, WANG Shaoli, YAO Naili, et al. A Clinical Observation on Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula for 40 Patients with Precancerous Lesions of Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2014, 55(4): 301-304.
[1]白宇宁,王少丽,姚乃礼,柳平,朱昱翎,马继征,彭艳.健脾通络解毒方加减辨治慢性萎缩性胃炎癌前病变40例临床观察[J].中医杂志,2014,55(04):301-304. DOI： 10.13288/j.11-2166/r.2014.04.010.

BAI Yuning, WANG Shaoli, YAO Naili, et al. A Clinical Observation on Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula for 40 Patients with Precancerous Lesions of Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2014, 55(4): 301-304. DOI： 10.13288/j.11-2166/r.2014.04.010.

摘要

目的观察健脾通络解毒方加减治慢性萎缩性胃炎（CAG）胃癌前病变（PLGC）的临床疗效。方法收集40例PLGC患者

给予健脾通络解毒方加减辨证治疗

每日1剂

治疗6个月后评定临床疗效。观察患者治疗前后主要临床症状（胃脘疼痛、胃脘胀满、胃脘痞塞、烧心、反酸、嗳气、胃寒、纳差、嘈杂）

胃镜下征象（黏膜苍白、血管透见、黏膜皱襞变薄、黏膜粗糙颗粒改变、肠化结节）及病理组织学（肠上皮化生、异型增生、腺体萎缩、慢性炎症、活动性）半定量积分情况。结果患者主要临床症状积分及总积分治疗前后比较

差异均有统计学意义（P<0.01）;胃镜下胃窦小弯各病变征象积分及总积分治疗前后比较

差异均有统计学意义（P<0.05或P<0.01）

胃角的黏膜苍白、血管透见、肠化结节积分及总积分治疗前后比较

差异均有统计学意义（P<0.05或P<0.01）;病理组织学胃窦小弯各病变积分及总积分治疗前后比较

差异均有统计学意义（P<0.05或P<0.01）

胃角的异型增生、慢性炎症、活动性积分及总积分治疗前后比较

差异均有统计学意义（P<0.05或P<0.01）;40例患者中显效1例（2.5%）

有效30例（75.0%）

无效9例（22.5%）

临床总有效31例（77.50%）。结论健脾通络解毒方加减辨证PLGC可明显改善临床症状、胃黏膜病变

临床疗效肯定。

Abstract

Objective To observe the therapeutic effect of Spleen-Supplementing Network Vessels-Freeing ToxinResolving Formula for precancerous lesions of chronic atrophic gastritis（ CAG）. Methods Forty patients with precancerous lesions of CAG were selected and given modified Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula one dose daily. The therapeutic effect was evaluated after 6-month treatment. The common symptoms

endoscopic signs and histopathologic changes were observed before and after treatment. Results There were significant differences between before and after treatment in the scores of main clinical symptoms and total score（ P < 0. 01）. There were significant differences between before and after treatment in the scores of signs in the lesser curvature and total score under gastroscope（ P = 0. 035

P = 0. 003

P = 0. 046

P < 0. 001

P < 0. 001）. There were significant differences between before and after treatment in the scores of pale mucous membranes

transparent vascular and intestinal metaplasia nodules in the gastric angle and total score（ P = 0. 010

P < 0. 001

P = 0. 002

P < 0. 001）. There were significant differences between before and after treatment in the scores of histopathologic lesions in the lesser curvature and total score（ P = 0. 001

P = 0. 002

P = 0. 030

P = 0. 001

P < 0. 001）. There were significant differences between before and after treatment in the scores of dysplasia

chronic inflammation and activity in the gastric angle and total score（ P = 0. 014

P = 0. 008

P < 0. 001

P = 0. 047）. There were 1 case（ 2. 5%） markedly effective

30 cases（ 75. 0%） effective and 9 cases（ 22. 5%） ineffective

with a total effective rate of 77. 50%（ 31 cases）. Conclusion Spleen-Supplementing Network Vessels-Freeing Toxin-Resolving Formula has a certain effect in blocking the development of precancerous lesions of CAG.

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