Bioinformatics Analysis on Molecular Mechanism of Xiyanping Injection for H1N1 Influenza A

LI Li; WANG Yanping; ZHAO Jing; JIANG Miao; Lü Cheng; Lü Aiping

doi:10.13288/j.11-2166/r.2014.04.019

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Bioinformatics Analysis on Molecular Mechanism of Xiyanping Injection for H1N1 Influenza A

更新时间：2021-11-17

- Bioinformatics Analysis on Molecular Mechanism of Xiyanping Injection for H1N1 Influenza A
- Journal of Traditional Chinese Medicine Vol. 55, Issue 4, Pages: 337-341(2014)
- 作者机构：
  
  中国中医科学院中医临床基础医学研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.04.019
  CLC： R511.7
- Published：2014
- 稿件说明：
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[1]李立,王燕平,赵静,姜淼,吕诚,吕爱平.喜炎平注射液防治甲型H1N1流感分子机制的生物信息学分析[J].中医杂志,2014,55(04):337-341.

LI Li, WANG Yanping, ZHAO Jing, et al. Bioinformatics Analysis on Molecular Mechanism of Xiyanping Injection for H1N1 Influenza A[J]. Journal of Traditional Chinese Medicine2014, 55(4): 337-341.
[1]李立,王燕平,赵静,姜淼,吕诚,吕爱平.喜炎平注射液防治甲型H1N1流感分子机制的生物信息学分析[J].中医杂志,2014,55(04):337-341. DOI： 10.13288/j.11-2166/r.2014.04.019.

LI Li, WANG Yanping, ZHAO Jing, et al. Bioinformatics Analysis on Molecular Mechanism of Xiyanping Injection for H1N1 Influenza A[J]. Journal of Traditional Chinese Medicine2014, 55(4): 337-341. DOI： 10.13288/j.11-2166/r.2014.04.019.

摘要

目的通过生物信息学方法

探讨喜炎平注射液防治甲型H1N1流感（简称甲流）的分子机制。方法以"Andrographolide"（穿心莲内酯）为检索词

在PubChem数据库中查找其相关生物学结果

根据结果确定穿心莲内酯的活性靶蛋白。以"H1N1 influenza A"（甲流）为检索词

在Gene数据库中查找甲流的相关基因。利用IPA生物信息学软件分别构建穿心莲内酯的活性靶蛋白及甲流相关基因的分子网络

并进行生物学作用通路及分子作用机制的解析。结果查找到穿心莲内酯的活性靶蛋白9个

甲流相关基因22个。二者构成的网络中共同分子为:Akt、Hsp90、Hsp27、PI3K、ERK1/2、NFkB、Proteasome、caspase、Jnk、P38MAPK、Pka、Pkc（s）、Ras、RNA polymeraseⅡ、Vegf

其中穿心莲内酯靶蛋白网络的分子大多与细胞周期、胚胎发育及细胞间信号传导有关;甲流相关基因网络中的分子大多与传染性疾病、炎症反应及免疫性疾病有关。二者共同作用的通路以细胞免疫通路为主

穿心莲内酯主要作用于该类通路中的AKT和NF-κB分子。结论喜炎平注射液可能通过调解细胞免疫通路中的AKT和NF-κB分子干预甲流。

Abstract

Objective To study the molecular mechanism of Xiyanping Injection（ Andrographolide） for H1N1 influenza A with bioinformatics methods. Methods Target proteins of Andrographolide were searched in PubChem and the related genes of H1N1 influenza A were search in NCBI Gene Database online. The data sets were uploaded to IPA bioinformatics software. Molecular networks and canonical pathways were compared and analyzed with Ingenuity Pathway Analysis（ IPA）. Results There were 9 target proteins of Andrographolide and 22 related genes of H1N1 influenza A. Their common molecules were Akt

Hsp90

Hsp27

PI3K

ERK1 /2

NFkB

Proteasome

caspase

Jnk

P38 MAPK

Pka

Pkc（ s）

Ras

RNA polymerase II

and Vegf. The network functions of Andrographolide were mostly associated with the cell cycle

embryonic development

and cell-to-cell signaling and interaction. The network functions of H1N1 influenza A were mostly associated with infectious diseases

inflammatory response and immunological diseases. Their common pathways were cell immune pathways. Andrographolide could regulate AKT and NF-κB. Conclusion Xiyanping Injection is effective for H1N1 influenza A possibly by regulating AKT and NF-κB of cell immune pathways.

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