Objective To study the possible mechanism of Fangji Fuling Decoction [decoction of Fangji（ Radix Stephaniae Tetrandrae

防己） and Fuling（ Poria

茯苓）

防己茯苓汤]for acute kidney injury（ AKI）. Methods Totally 39 Wistar rats were randomized into the normal group

model group and Fangji Fuling Decoction group

with 13 in each. The AKI rat models were established by intraperitoneal injection of 5 mg / kg lipopolysaccharide（ LPS） in the model group and Fangji Fuling Decoction group. The Fangji Fuling Decoction group was gavaged with 18. 375 g /（ kg·d） Fangji Fuling Decoction twice daily from 7 days before injection. The normal group and model group were gavaged with equal volume of normal saline at the corresponding time points. The mortality within 24 h after intraperitoneal injection was calculated. The contents of serum creatinine（ SCr） and blood urea nitrogen（ BUN）

urine volume and the expressions of urinary N-acetyl-β-glucosaminidase（ NAG）

kidney injury molecule-1（ KIM-1）

KIM-1 mRNA

neutrophil gelatinase-associated lipocalin（ NGAL）

and NGAL mRNA were detected. Results The mortality within 24 h after injection in the model group and Fangji Fuling Decoction group was 53. 8% and 38. 5% respectively. There was no death in the normal group. The mortality in the Fangji Fuling Decoction group was significantly lower than that in the model group（ P < 0. 05）. The contents of SCr and BUN

urine volume and the expressions of NAG

KIM-1

KIM-1mRNA

NGAL and NGAL mRNA in the Fangji Fuling Decoction group was significantly lower than those in the model group（ P < 0. 05）. Conclusion Fangji Fuling Decoction is effective for AKI

which may be relevant to inhibiting the expressions of KIM-1

KIM-1mRNA

NGAL and NGAL mRNA.