Objective To observe the effects of Tongxinluo Capsule（ 通心络胶囊

TXL） on diastolic function and atherosclerosis. Methods Totally 240 New Zealand rabbits were randomized into the normal group

model group

atorvastatin group and TXL high

medium and low dose groups

with 40 in each. The normal group was given normal diet. The hyperlipidemia models were established with high-fat diet in other groups. The atorvastatin group was gavaged with 2. 5 mg / kg atorvastatin solution and TXL high

medium and low dose groups were gavaged with 0. 6

0. 3 and 0. 15 g / kg TXL solution once daily during modeling. The intragastric volume was 3ml / kg. The lipid levels

microvessel density（MVD） in the aortic wall and changes of endothelium-dependent vasodilation were detected on the 3rd day

1st week

2nd week

4th week and 6th week after experiment. The correlation between diastolic function and MVD was analyzed. Results The levels of total cholesterol（TC）

triglycerides（TG） and low-density lipoprotein cholesterol（LDL-C） were significantly decreased in the TXL high and medium dose groups and atorvastatin group（P <0. 05 or P <0. 01）. Comparing with the model group

the aortic diastolic rate was significantly increased but the MVD was significantly decreased in the TXL high dose group and atorvastatin group on the 4th week and 6th week of administration（P < 0. 05 or P < 0. 01）. Comparing with the model group

the aortic diastolic rate was significantly increased but the MVD was significantly decreased in the TXL medium dose group on the 6th week of administration（P <0. 05）. The endothelium-dependent vasodilation and MVD was negatively correlated（r =-0. 824

P <0. 01）. Conclusion TXL can improve vasodilation and delay the development of atherosclerosis by reducing lipid levels and inhibiting the microvascular breeding.