Objective To study the effect of Yiqi Shengxue Formula（ qi-boosting blood-engendering formula） on bone marrow suppression（ BMS） after adjuvant chemotherapy for breast cancer. Methods Eighty breast cancer patients who were undergoing adjuvant chemotherapy after operation were randomized into the observation group and control group

with 40 in each. The control group was given combination chemotherapy of docetaxel and epirubicin by intravenous infusion on the 1st day of a cycle（ 21 days） and for two cycles. The observation group was added with Yiqi Shengxue Formula one dose daily from one week before chemotherapy to the end of chemotherapy. The counts of white blood cell（ WBC）

hemoglobin（ HGB） and platelet（ PLT） were detected

and the quality of life（ QOL） was evaluated in both groups before and after chemotherapy. Results The incidence of WBC reduction in the observation group and control group was 37. 5% and 72. 5% respectively

with a significant difference between groups（ P < 0. 01）. The incidence of HGB reduction in the observation group and control group was 40. 0% and 70. 0% respectively

with a significant difference between groups（ P < 0. 05）. The incidence of PLT reduction in the observation group and control group was 25. 0% and 65. 0% respectively

with a significant difference between groups（ P < 0. 01）. The QOL scores in both groups were significantly improved after chemotherapy（ P < 0. 05）

especially in the observation group（ P < 0. 05）. The QOL was declined in 7. 5% patients in the observation group and in 45. 0% patients in the control group

with a significant difference between groups（ P < 0. 01）. Conclusion Yiqi Shengxue Formula combined with chemotherapy can effectively reduce the extent and incidence of BMS and improve QOL of patients.