Objective To study the pharmacological mechanism of Lianhua Qingwen Granules /Capsules for H1N1 influenza A by biological network method. Methods The H1N1 influenza-related genes or proteins were confirmed by text mining. The target proteins of Lianhua Qingwen Granules / Capsules were obtained by searching the PubChem Database. The protein interaction networks of H1N1 influenza A and target protein interaction networks of Lianhua Qingwen Granules / Capsules were constructed and the latter was mapped to the former to establish the target protein interaction networks of Lianhua Qingwen Granules / Capsules against H1N1 influenza. The network topology and gene ontology（ GO） analysis were conducted. Results The pharmacological effect of Lianhua Qingwen Granules / Capsules was mainly related to inhibitory regulation of cells to external stimulation

regulation of apoptosis and signal transduction. The protein kinase B（ AKT1）

caspase 3（ CASP3）

mitogen-activated protein kinase 1（ MAPK1）

tumor gene p53（ TP53）

nuclear factor-κB p65（ RELA）

nuclear factor-κB p50（ NFKB1）

and heat shock protein 90-alpha（ HSP90AA1） was involved. Conclusion Lianhua Qingwen Granules / Capsules can inhibit the disease progression of H1N1 influenza A possibly by affecting AKT1 and CASP3 signaling pathways

regulating apoptosis

and reducing viral replication.