Reflections on Targeted Therapy for Myocardial No-Reflow After Revascularization of Acute Myocardial Infarction

SHI Dazhuo; GAO Zhuye; DUAN Wenhui

doi:10.13288/j.11-2166/r.2014.10.007

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Reflections on Targeted Therapy for Myocardial No-Reflow After Revascularization of Acute Myocardial Infarction

更新时间：2021-11-17

- Reflections on Targeted Therapy for Myocardial No-Reflow After Revascularization of Acute Myocardial Infarction
- Journal of Traditional Chinese Medicine Vol. 55, Issue 10, Pages: 832-834(2014)
- 作者机构：
  
  中国中医科学院西苑医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.10.007
  CLC： R542.22
- Published：2014
- 稿件说明：
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[1]史大卓,高铸烨,段文慧.急性心肌梗死血运重建后心肌组织无复流和靶向治疗的思考[J].中医杂志,2014,55(10):832-834.

SHI Dazhuo, GAO Zhuye, DUAN Wenhui. Reflections on Targeted Therapy for Myocardial No-Reflow After Revascularization of Acute Myocardial Infarction[J]. Journal of Traditional Chinese Medicine2014, 55(10): 832-834.
[1]史大卓,高铸烨,段文慧.急性心肌梗死血运重建后心肌组织无复流和靶向治疗的思考[J].中医杂志,2014,55(10):832-834. DOI： 10.13288/j.11-2166/r.2014.10.007.

SHI Dazhuo, GAO Zhuye, DUAN Wenhui. Reflections on Targeted Therapy for Myocardial No-Reflow After Revascularization of Acute Myocardial Infarction[J]. Journal of Traditional Chinese Medicine2014, 55(10): 832-834. DOI： 10.13288/j.11-2166/r.2014.10.007.

摘要

急性心肌梗死（AMI）相关血管血运重建治疗可显著降低患者并发症发生率和病死率

提高生活质量

但AMI相关冠状动脉血运重建后一年内心血管病事件发生率仍较高

现代医学对血运重建后的系统炎症反应、心肌组织无复流、再灌注损伤、血管内皮功能障碍等病理环节尚缺乏真正理想的对策。中药及其复方药效成分极其复杂

作用环节的靶向性虽不如化学药物明确

但多作用环节的综合效应有不可替代的优势。因此

在现代医学基础上

结合传统医学

系统研究中药、复方不同有效成分及其相互组合干预AMI血运重建后多个病理环节的机理

有望为改善AMI的二级预防效果提供新的安全有效的干预模式。

Abstract

The revascularization of acute myocardial infarction（ AMI） can obviously reduce the complications and mortality and improve quality of life.But the incidence of cardiovascular disease is still around 18% within one year after revascularization of AMI.The countermeasures to prevent systemic inflammation

myocardial no-reflow

reperfusion injury and vascular endothelial dysfunction after revascularization of AMI are still lacking.The effective components of TCM medicinal and compound recipes are extremely complex

but their combined efficacy is still irreplaceable.Therefore

TCM medicinal and compound recipes are expected to improve the secondary prevention of AMI and provide a new

safe and effective intervention model.

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