Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome

ZHOU Qingbing; WANG Hongzhi; YANG Xiupeng; GUO Xiaoqing; YANG Xiaohong; XU Yonggang; HU Xiaomei; MA Rou

doi:10.13288/j.11-2166/r.2014.10.009

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Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome

更新时间：2021-11-17

- Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome
- Journal of Traditional Chinese Medicine Vol. 55, Issue 10, Pages: 838-841(2014)
- 作者机构：
  
  中国中医科学院西苑医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.10.009
  CLC： R551.3
- Published：2014
- 稿件说明：
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[1]周庆兵,王洪志,杨秀鹏,郭小青,杨晓红,许勇钢,胡晓梅,麻柔.青黄散及健脾补肾方药联合西药治疗骨髓增生异常综合征107例临床观察[J].中医杂志,2014,55(10):838-841.

ZHOU Qingbing, WANG Hongzhi, YANG Xiupeng, et al. Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome[J]. Journal of Traditional Chinese Medicine2014, 55(10): 838-841.
[1]周庆兵,王洪志,杨秀鹏,郭小青,杨晓红,许勇钢,胡晓梅,麻柔.青黄散及健脾补肾方药联合西药治疗骨髓增生异常综合征107例临床观察[J].中医杂志,2014,55(10):838-841. DOI： 10.13288/j.11-2166/r.2014.10.009.

ZHOU Qingbing, WANG Hongzhi, YANG Xiupeng, et al. Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome[J]. Journal of Traditional Chinese Medicine2014, 55(10): 838-841. DOI： 10.13288/j.11-2166/r.2014.10.009.

摘要

目的观察青黄散加补肾健脾中药联合西药治疗骨髓增生异常综合征（MDS）的临床疗效。方法收集107例MDS患者

给予青黄散、健脾补肾汤药及雄性激素

治疗时间为3个月

检测治疗前后患者外周血白细胞（WBC）计数、血红蛋白（Hb）含量、血小板（PLT）计数

并评价血液学指标疗效、不同分型疗效、不同国际预后积分系统（IPSS）危险度分层疗效、不同遗传学分组疗效。结果 107例患者治疗前后外周血细胞计数比较

WBC、PLT治疗前后差异无统计学意义（P>0.05）

Hb含量治疗前后差异有统计学意义（P<0.01）。Hb与WBC疗效比较、Hb与PLT疗效比较差异均有统计学意义（P<0.01）

而WBC与PLT疗效比较差异无统计学意义（P>0.05）。两组患者不同分型疗效比较、不同IPSS危险度分层疗效比较、不同遗传学分组疗效比较差异均无统计学意义（P>0.05）。结论青黄散加健脾补肾中药联合西药综合治疗MDS具有确切的临床疗效

主要对红系起作用

疗效与分型、IPSS危险度分层及遗传学分组无明显相关性。

Abstract

Objective To observe the efficacy of Qinghuang Powder

Spleen-Strengthening Kidney-Supplementing Formula（ SKF） and western medicine for myelodysplastic syndrome（ MDS）.Methods Totally 107 cases of outpatient with MDS were included and treated with Qinghuang Powder

SKF and androgens.The treatment lasted for 3 months.The white blood cell（ WBC） count

hemoglobin（ Hb） level and platelet（ PLT） count were detected before and after treatment.The efficacy of blood cells

types

International Prognostic Scoring System（ IPSS） and genetic groups were evaluated.Results There was no significant difference between before and after treatment in WBC and PLT（ P > 0.05）.There was a significant difference between before and after treatment in Hb（ P < 0.05）.There was a significant difference between the efficacy of Hb and WBC（ P < 0.01）.There was a significant difference between the efficacy of Hb and PLT（ P < 0.01）.There was no significant difference between the efficacy of WBC and PLT（ P > 0.05）.There was no significant difference in the efficacy of types

IPSS and genetic groups（ P >0.05）.Conclusion The combo therapy of Qinghuang Powder

SKF and western medicine is effective for MDS and mainly affects erythroid cells.The efficacy is not obviously correlated with types

IPSS and genetic groups.

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