Objective To observe the therapeutic effect of Qingyang Toujie Mixture combined with western medicine and its effects on vascular injury in patients with systemic lupus erythematosus（ SLE）. Methods A prospective single- blind randomized controlled method was used. Totally 42 SLE patients with yin deficiency syndrome were randomized into the treatment group with 22 patients and control group with 20 patients. Twelve healthy persons were selected as the healthy group. Both the treatment and control groups were given western medicine. The treatment group was added with Qingyang Toujie Mixture one dose daily. The control group was added with placebo one dose daily. Both groups were treated for 6 months. The Systemic Lupus Erythematosus Disease Activity Index（ SLEDAI）

TCM syndrome score

prednisone dosage and adverse reactions were observed before and after treatment. The expressions of soluble thrombomodulin（ sTM） and von Willebrand factor（ vWF） were observed and compared with the healthy group. Results The SLEDAI scores

TCM syndrome scores and prednisone dosage were significantly decreased in the treatment group and control group after treatment（ P < 0. 01）

especially in the treatment group（ P < 0. 01）. Comparing with the healthy group

the levels of vWF and sTM were significantly higher in the treatment group and control group before treatment（ P < 0. 01）. The levels of vWF and sTM were significantly decreased in the treatment group after treatment（ P < 0. 01）. The cases of adverse reactions in the treatment group were significantly fewer than those in the control group（ P < 0. 01）. Conclusion The combo therapy of Qingyang Toujie Mixture and western medicine can relieve the clinical symptoms

reduce the hormone dosage

decrease vWF and sTM expression

and alleviate vascular injury in SLE patients with yin deficiency syndrome.