Objective To study the medication characteristics of Shenfu Injection for critical illness in the real world. Methods The information of critical patients injected with Shenfu Injection were collected from hospital information system（ HIS） in 20 first level hospitals nationwide. The disease distribution

administration route

administration time and concomitant medications were analyzed. The relational analysis was used to analyze the combination medications of Shenfu Injection applied in critical patients. Results There were 7896 critical patients injected with Shenfu Injection with an average age of（ 68. 90 ± 13. 73） years old. The main diseases were heart failure

coronary heart disease and hypertension. The main TCM diseases were dyspnea syndrome

chest discomfort and apoplexy. The main TCM syndromes were qi deficiency and blood stasis syndrome

qi- yin deficiency syndrome

and phlegm- stasis syndrome. The treatment course was mostly within 3 to 7 days and usually with a dose of 60 ml. Spironolactone Tablets

furosemide and isosorbide esters were commonly combined. Conclusion Shenfu Injection is commonly used in critical illness such as senile cardiovascular and cerebrovascular diseases

and usually with a combination of Spironolactone Tablets

furosemide or isosorbide esters.