Objective To observe the effects and mechanism of Shengjing Formula（formula to improve the sperm production

生精方）on infertile patients caused by oligoasthenospermia with kidney deficiency syndrome. Methods Totally 67cases of infertility caused by oligoasthenospermia were randomized into the treatment group of 34cases and control group of 33cases.The treatment group was given Shengjing Formula（生精方）one dose daily.The control group was given Wuzi Yanzong Pills（五子衍宗丸）6g each time

twice daily.The treatment lasted for 3months.The expression of H19was detected before and after treatment.The syndrome scores

semen analysis results and adverse reactions were observed.The clinical pregnancy rates of spouses were evaluated. Results The loss rate of H19was significantly improved in the treatment group after treatment（P<0.05）.The syndrome scores

sperm density and sperm motility（a+b class）were significantly improved in both groups after treatment（P<0.05or P<0.01）

especially in the treatment group（P<0.05）.The clinical pregnancy rate in the treatment group and control group was 55.88% and 33.33%respectively

with a significant difference between groups（P<0.01）. Conclusion Shengjing Formula（生精方）can improve semen quality and clinical pregnancy rate possibly by improving the expression of H19imprinted genes in human sperm.