Effects of Weiwei Granules on the Expressions of Bcl-2 and PCNA in Mucosa of Rats With Chronic Atrophic Gastritis

HUANG Bin; XIE Weichang; LI Jian; GUO Shaoju; FENG Chunxia

doi:10.13288/j.11-2166/r.2014.13.018

您当前的位置：

首页 >

文章列表页 >

Effects of Weiwei Granules on the Expressions of Bcl-2 and PCNA in Mucosa of Rats With Chronic Atrophic Gastritis

更新时间：2021-11-17

- Effects of Weiwei Granules on the Expressions of Bcl-2 and PCNA in Mucosa of Rats With Chronic Atrophic Gastritis
- Journal of Traditional Chinese Medicine Vol. 55, Issue 13, Pages: 1139-1141(2014)
- 作者机构：
  
  1. 深圳市中医院
  2. 广州中医药大学深圳临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.13.018
  CLC： R573.32
- Published：2014
- 稿件说明：
移动端阅览
[1]黄彬,谢伟昌,李健,郭绍举,冯春霞.萎胃颗粒对慢性萎缩性胃炎大鼠胃黏膜Bcl-2和PCNA表达的影响[J].中医杂志,2014,55(13):1139-1141.

HUANG Bin, XIE Weichang, LI Jian, et al. Effects of Weiwei Granules on the Expressions of Bcl-2 and PCNA in Mucosa of Rats With Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2014, 55(13): 1139-1141.
[1]黄彬,谢伟昌,李健,郭绍举,冯春霞.萎胃颗粒对慢性萎缩性胃炎大鼠胃黏膜Bcl-2和PCNA表达的影响[J].中医杂志,2014,55(13):1139-1141. DOI： 10.13288/j.11-2166/r.2014.13.018.

HUANG Bin, XIE Weichang, LI Jian, et al. Effects of Weiwei Granules on the Expressions of Bcl-2 and PCNA in Mucosa of Rats With Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2014, 55(13): 1139-1141. DOI： 10.13288/j.11-2166/r.2014.13.018.

摘要

目的探讨萎胃颗粒治疗慢性萎缩性胃炎（CAG）的可能作用机制。方法将50只SD大鼠随机分为正常组、模型组和萎胃颗粒低、中、高剂量组

每组10只。除正常组外

其余各组大鼠复制CAG模型

造模后正常组和模型组给予10ml/kg自来水灌胃

萎胃颗粒低、中、高剂量组分别给予萎胃颗粒1.8、3.6、7.2g/d灌胃

共连续12周。采用免疫组织化学方法检验各组大鼠胃黏膜增殖细胞核抗原（PCNA）和抑凋亡基因（Bcl-2）表达。结果与正常组比较

模型组大鼠胃黏膜Bcl-2、PCNA表达显著增多（P<0.01）;与模型组比较

萎胃颗粒各治疗组Bcl-2均有明显下降（P<0.01）;与萎胃颗粒低剂量组比较

中剂量组Bcl-2下降（P<0.01）;与萎胃颗粒中剂量组比较

高剂量组Bcl-2下降（P<0.01）。与模型组比较

萎胃颗粒各治疗组的PCNA阳性表达率均有明显下降（P<0.01）;与萎胃颗粒低剂量组比较

中剂量组阳性表达率下降（P<0.01）;与萎胃颗粒中剂量组比较

高剂量组阳性表达率下降（P<0.01）。结论萎胃颗粒可能通过抑制CAG大鼠胃黏膜Bcl-2和PCNA的表达

调节细胞的增殖和凋亡

从而改善CAG胃黏膜病变。

Abstract

Objective To research the effects and mechanism of Weiwei Granules on chronic atrophic gastritis（CAG）. Methods Totally 50SD rats were randomized into the normal group

model group and Weiwei Granules low-dose（1.8g/d）

middle-dose（3.6g/d）and high-dose（7.2g/d）groups

with 10in each.The CAG models were established in all groups except the normal group with comprehensive method.The intragastric administration lasted for 12weeks.The expressions of Bcl-2and proliferating cell nuclear antigen（PCNA）in mucosa of CAG rats were observed with immunohistochemical method. Results Comparing with the model group

the OD values of Bcl-2in Weiwei Granules groups were significantly decreased（P<0.01）.Comparing with the Weiwei Granules low-dose group

the OD value was significantly decreased in the middle-dose group（P<0.01）.Comparing with the Weiwei Granules middle-dose group

the OD value was significantly decreased in the high-dose group（P<0.01）.Comparing with the model group

the positive expression rate of PCNA in Weiwei Granules groups were significantly decreased（P<0.01）.Comparing with the Weiwei Granules low-dose group

the positive expression rate of PCNA was significantly decreased in the middle-dose group（P<0.01）.Comparing with the Weiwei Granules middle-dose group

the positive expression rate of PCNA was significantly decreased in the high-dose group（P<0.01）. Conclusion Weiwei Granules can relieve the pathological state of gastric mucosal lesions and avoid stomach cancer possibly by inhibiting the expressions of Bcl-2and PCNA in mucosa of CAG rats and regulating the proliferation and apoptosis of cells.

关键词

Keywords

references

查看原文

Views

253

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Xiaopi Granules on Proliferation and Apoptosis in the Gastric Mucosa of Chronic Atrophic Gastritis Rats with Atypical Hyperplasia

A Randomized Controlled Trial of Jianpi Jiedu Formulation （健脾解毒方） in the Treatment of Kimura-Takemoto Closed-Type Atrophic Gastritis with Spleen Deficiency and Damp-Heat Syndrome

SHAN Zhaowei's Experience in Treating Chronic Atrophic Gastritis with the Three-Unblocking Method

Prevention and Treatment of Inflammation-Cancer Transformation in Chronic Atrophic Gastritis Based on Collateral Disease Theory

Clinical Study on the Treatment of 70 Cases Chronic Atrophic Gastritis with Intestinal Metaplasia Using Xianglian Huazhuo Granules （香连化浊颗粒）：A Randomized，Double-Blind，Placebo-Controlled Trial

Related Author

ZHAO Jing1

MENG Jie2

YANG Jinxiang3

PENG Jisheng2

GU Bingyan

QIN Danping

YANG Xinyan

ZHANG Yusen

Related Institution

The 3rd Affiliated Hospital of Beijing University of Chinese Medicine

Dongfang Hospital,Beijing University of Chinese Medicine

Zhejiang University

Huzhou Central Hospital

Zhejiang Provincial Hospital of Traditional Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰