Objective To observe the efficacy of modified Yishen Tongluo Formula（formula for reinforcing kidney and freeing vessels

益肾通络方） for erectile dysfunction（ED）. Methods Sixty cases of ED were randomized into the treatment group and control group

with 30 in each. The patients in the treatment group were orally taken modified Yishen Tongluo Formula one dose daily. The patients in the control group were orally taken 10 mg of Tadalafil Tablets once every three days 30 minutes before bedtime. The treatment lasted for 4 weeks. The efficacy was evaluated after treatment. The scores of International Index of Erectile Function-5（IIEF-5） and TCM symptoms were compared between groups before and after treatment. Results The total effective rate of the treatment group and control group was 76. 6% and 83. 3% respectively

with no significant difference between groups（P > 0. 05）. The scores of IIEF-5 were significantly increased in both groups after treatment（P < 0. 05）. There was no significant difference between groups in the scores of IIEF-5 after treatment（P > 0. 05）. The scores of impotence

emotional depression

dizziness

tinnitus

weakness

sexual desire and ejaculation feelings were significantly decreased in the treatment group after treatment（P < 0. 05）. There were significant differences between groups in the scores of dizziness

tinnitus

weakness

sexual desire and ejaculation feelings（P < 0. 05）. Conclusion The efficacy of Yishen Tongluo Formula is similar to Tadalafil Tablets in treating ED. But Yishen Tongluo Formula can better relieve symptoms.