Objective To observe the lipid-lowering effects and possible mechanism of Qingjian Granules（轻健颗粒） on rats with nutrition obesity. Methods Eighty 21-day-old male SD rats just after weaning were randomized into the blank control group of 10 cases and high-fat modeling group of 70 cases. The blank control group was given basal diet. The high-fat modeling group was given high fat diet to establish nutrition obesity models. Eight weeks later

forty rat models were randomized into the model control group and Qingjian Granules high-dose

middle-dose and low-dose groups

with 10 in each. The rats in Qingjian Granules high-dose

middle-dose and low-dose groups were gavaged with 34. 5 g /（kg·d）

17. 25 g /（kg·d） and 8. 55 g /（ kg·d） of Qingjian Granules respectively. The rats in blank control group and model control group were gavaged with equal volume of normal saline for 8 weeks. The body weight and body fat weight were measured. The Lee’ s index was calculated. The levels of total cholesterol（TC）

triglyceride（TG）

low density lipoprotein（LDL）

high density lipoprotein（HDL） and high-sensitivity C-reactive protein（hs-CRP） were detected. Results Comparing with the model groups

the weight

body fat weight

Lee’s index

TC

TG

LDL and hs-CRP were significantly decreased but the HDL levels were significantly increased in the Qingjian Granules high-dose

middle-dose and low-dose groups（P < 0. 01）. Conclusion Qingjian Granules can reduce the weight and body fat weight of rats with nutrition obesity

which may be relevant to regulating the levels of blood lipids and hs-CRP.