Clinical Observation on Oral and External Administration of TCM Herbs for 30 Cases of Acute Attack of Gouty Arthritis With Damp-Heat Stasis Obstruction Syndrome

WANG Yuan; LIU Jian; HUANG Chuanbing; ZONG Ruikai; LI Ming

doi:10.13288/j.11-2166/r.2014.15.011

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Clinical Observation on Oral and External Administration of TCM Herbs for 30 Cases of Acute Attack of Gouty Arthritis With Damp-Heat Stasis Obstruction Syndrome

更新时间：2021-11-17

- Clinical Observation on Oral and External Administration of TCM Herbs for 30 Cases of Acute Attack of Gouty Arthritis With Damp-Heat Stasis Obstruction Syndrome
- Journal of Traditional Chinese Medicine Vol. 55, Issue 15, Pages: 1299-1302(2014)
- 作者机构：
  
  安徽中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.15.011
  CLC： R259
- Published：2014
- 稿件说明：
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[1]汪元,刘健,黄传兵,纵瑞凯,李明.中药内服外敷治疗湿热瘀阻型痛风性关节炎急性发作30例临床观察[J].中医杂志,2014,55(15):1299-1302.

WANG Yuan, LIU Jian, HUANG Chuanbing, et al. Clinical Observation on Oral and External Administration of TCM Herbs for 30 Cases of Acute Attack of Gouty Arthritis With Damp-Heat Stasis Obstruction Syndrome[J]. Journal of Traditional Chinese Medicine2014, 55(15): 1299-1302.
[1]汪元,刘健,黄传兵,纵瑞凯,李明.中药内服外敷治疗湿热瘀阻型痛风性关节炎急性发作30例临床观察[J].中医杂志,2014,55(15):1299-1302. DOI： 10.13288/j.11-2166/r.2014.15.011.

WANG Yuan, LIU Jian, HUANG Chuanbing, et al. Clinical Observation on Oral and External Administration of TCM Herbs for 30 Cases of Acute Attack of Gouty Arthritis With Damp-Heat Stasis Obstruction Syndrome[J]. Journal of Traditional Chinese Medicine2014, 55(15): 1299-1302. DOI： 10.13288/j.11-2166/r.2014.15.011.

摘要

目的观察黄芩清热除痹胶囊内服配合芙蓉膏外敷治疗痛风性关节炎急性发作的临床疗效。方法60例痛风性关节炎患者随机分为治疗组与对照组各30例

两组均予美洛昔康分散片7.5 mg

每日2次口服为基础治疗

治疗组加用黄芩清热除痹胶囊每次3粒

每日3次口服

并配合芙蓉膏外敷

每次6h

每日2次

两组疗程均为2周。观察两组患者关节疼痛起效时间

治疗前后中医证候评分、疼痛VAS评分、血沉（ESR）、C反应蛋白（CRP）、血尿酸（UA）水平

评价两组的临床疗效及安全性。结果治疗组临床疗效总有效率为100%

对照组总有效率为93.3%

治疗组明显高于对照组（P<0.01）;治疗组疼痛平均起效时间为（2.60±0.67）天

而对照组平均起效时间为（4.00±0.95）天

治疗组明显短于对照组（P<0.01）;两组治疗后均能显著降低患者中医证候积分、疼痛VAS评分、ESR、CRP水平（P<0.05或P<0.01）

治疗组在降低中医证候积分、疼痛VAS评分、ESR、CRP及UA水平方面优于对照组（P<0.05或P<0.01）;两组患者均未见明显不良反应。结论黄芩清热除痹胶囊内服配合芙蓉膏外敷能有效控制痛风性关节炎急性发作症状

减轻患者疼痛

降低ESR、CRP及UA水平

起效迅速

且安全性良好。

Abstract

Objective To observe the efficacy of Huangqin Qingre Chubi Capsules [capsules of Huangqin（Scutellariae Radix） to clear heat and eliminate impediment]combined with Furong Plaster for acute attack of gouty arthritis. Methods Sixty patients were randomized into the treatment group and control group

with 30 in each.Both groups were given 7. 5 mg Meloxicam Dispersible Tablets twice daily. The treatment group was added with Huangqin Qingre Chubi Capsules 3 capsules each time and 3 times daily with oral administration and Furong Plaster(applied topically for 6h each time and twice daily. The treatment lasted for 2 weeks. The onset time for joint pain

TCM syndrome score

visual analogue scale（ VAS） pain score

erythrocyte sedimentation rate（ ESR）

C-reactive protein（CRP）

uric acid（UA） level were observed before and after treatment in both groups

and efficacy and safety were evaluated. Results The total effective rate of the treatment group and control group was 100% and 93. 3%respectively

with a significant difference between groups（ P < 0. 01）. The average onset time for pain in the treatment group and control group was（2. 60 ± 0. 67） d and（4. 00 ± 0. 95） d respectively

with a significant difference between groups（P < 0. 01）. The total TCM syndrome score

VAS score

ESR level and CRP level were significantly decreased in both groups after treatment（ P < 0. 05 or P < 0. 01）. The treatment group was superior to the control group in reducing the total TCM syndrome score

VAS score

ESR level

CRP level and UA level（P < 0. 05 or P <0. 01）. There was no obvious adverse reaction in both groups. Conclusion Huangqin Qingre Chubi Capsules combined with Furong Plaster is effective for acute attack of gouty arthritis. The treatment can relieve pain and reduce the levels of ESR

CRP and UA with a rapid onset and good safety.

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