Objective To evaluate the efficacy and safety of auricular electro-acupuncture（ EA） on auricular points ‘heart’（ CO15） and ‘spleen’（ CO13） for depression with heart-spleen deficiency syndrome. Methods Totally 48 depression patients with heart-spleen deficiency syndrome were randomized into the treatment group of 23 cases and control group of 21 cases. The treatment group was given auricular EA on CO15 and CO13 for 20 minutes twice daily. The control group was given auricular EA on ear points of‘shoulder’and‘elbow’for 20 minutes twice daily. The patients were treated 5 days weekly and the treatment lasted for 4 weeks. The scores of Hamilton Rating Scale for Depression-24 edition（ 24HAMD）

Self-rating Depression Scale（ SDS） and Traditional Chinese Medicine（ TCM） Syndrome Scale were compared. The efficacy was evaluated. The adverse reactions were recorded. Results The total effective rate of the treatment group and control group was 60. 87% and 10. 53%

respectively

with a significant difference between groups（ P < 0. 01）. The scores of 24 HAMD

SDS and TCM Syndrome Scale were significantly decreased in both groups after treatment（ P < 0. 01）

especially in the treatment group（ P < 0. 01）. There was no adverse reaction in both groups. Conclusion Auricular EA on CO15 and CO13 is effective and safe for depression. It can obviously relieve the symptoms of patients with depression.