Objective To study the effects of Xuesaitong Capsules on the repair and regeneration of autologous neural stem cells in infarcted brain tissue of rats. Methods The middle cerebral artery ischemia-reperfusion injury model was established with modified Zea-Longa method. The rat models were randomized into the model group and Xuesaitong Capsules high-dose

middle-dose and low-dose groups

with 40 in each. Forty healthy rats were selected as the normal group. Xuesaitong Capsules high-dose

middle-dose and low-dose groups were gavaged with 60 mg /（ 100g·d）

40 mg /（ 100 g·d） and 20 mg /（ 100 g·d） of Xuesaitong Capsules respectively. The normal group and model group were gavaged with same volume of normal saline. The intragastric administration lasted for 28 day. Eight rats were sacrificed on the 1st

3rd

7th

14 th and 28 th day after administration respectively to detect the expressions of 5-bromodeoxyuridine（ Brdu）

microtubule associated protein-2（ MAP-2）

glial fibrillary acidic protein（ GFAP）and IIIβ-Tubulin. Results The Brdu

MAP-2

GFAP and IIIβ-Tubulin positive cells were occasionally seen in the normal group. Comparing with the normal group

the Brdu

MAP-2

GFAP and IIIβ-Tubulin positive cells were significantly increased in the model group and Xuesaitong Capsules high-dose

middle-dose and low-dose groups（ P <0. 05）. Comparing with the model group at the same time point

the Brdu

MAP-2

GFAP and IIIβ-Tubulin positive cells were significantly increased in Xuesaitong Capsules high-dose

middle-dose and low-dose groups（ P < 0. 05）.Conclusion Xuesaitong Capsules can promote the proliferation and differentiation of neural stem cells in infarcted brain tissue and improve the repair and regeneration of damaged brain tissue.