Objective To study the effect of Shenqi Fuzheng Injection（ 参芪扶正注射液

SFI） on aspartate aminotransferase（ AST） in real world with propensity score analysis.Methods Patients aged 18 to 80 years and injected with SFI were selected as the observation group according to Hospital Information System（ HIS） in 20 hospitals.Patients used other traditional Chinese medicine injections with similar efficacy were chosen as the control group.The bias of confounding factors was balanced with propensity score analysis.The effect of SFI on AST level was analyzed with Logistic regression.Results The abnormality of AST was small in the observation group as compared with the control group after balancing 57 confounding factors

but with no significant difference between groups.Sensitivity analysis was not sensitive to the potential bias.There was no unobserved variable in this study.Conclusion The effect of SFI Injection on the abnormality of AST is not significant according to HIS data and research.