Objective To observe the effects of Compound Yibazhen on blood pressure（ BP） and kidney in spontaneous hypertensive rats（ SHR）. Methods Thirty SHR were randomized into the model group

captopril group and Compound Yibazhen group

with 10 in each. Another 10 Wistar rats were chosen as the normal group. The captopril group was given 22. 5 mg /（ kg·d） Captopril Tablets. The Compound Yibazhen group was given 15. 5 g /（ kg·d） Compound Yibazhen. The normal group and model group were gavaged with equal volume of normal saline.The administration lasted for 8 successive weeks. The systolic blood pressure and diastolic blood pressure were detected before and after 2-week

4-week

6-week and 8-week administration. The levels of urea

creatinine（ Crea）

microalbuminuria（ mAlb）

β2-microglobulin（ β2-MG） and N-acetyl-β-D-glucosidase（ NAG） were detected before and after administration. The tubular damage was observed by taking kidney and HE staining. Results The systolic blood pressure and diastolic blood pressure at each time point in the model group were significantly higher than those in the normal group after administration（ P < 0. 01）. The systolic blood pressure and diastolic blood pressure at each time point in the captopril group and Compound Yibazhen group were significantly lower than those in the model group after administration except after 2-week administration in the Compound Yibazhen group（ P < 0. 05 or P <0. 01）. The levels of mAlb and NAG in the model group were significantly higher than those in the normal group after administration（ P < 0. 01）. The NAG level in the captopril group and Compound Yibazhen group were significantly lower than that in the model group after administration（ P < 0. 05 or P < 0. 01）. The kidneys were significantly damaged in the model group. Compound Yibazhen could slightly reduce the damage of renal arterioles. Conclusion Compound Yibazhen can reduce kidney damage and lower BP to treat hypertensive nephropathy and kidney damage.