Objective To research the immunity characteristics of patients with infectious diseases. Methods A prospective

multi-center

large sample and registration method was used. The serums of patients with infectious diseases were collected and the immunological parameters such as cyclic adenosine monophosphate（ cAMP）

interleukin-1β（ IL-1β）

interleukin-4（ IL-4）

interleukin-6（ IL-6）

interleukin-8（ IL-8）

macrophage inflammatory protein 1β（ MIP-1β）

prostaglandin E2（ PGE2） and tumor necrosis factor-α（ TNF-α） were detected. The primary disease

disease duration

fever situation and different characteristics of TCM syndromes were analyzed. Results Totally 2 445 patients with infectious diseases were collected and their immunological parameters were detected. There were significant differences between different body temperatures in the levels of IL-6

cAMP

PGE-2 and TNF-α（ P <0.05 or P <0. 01）. The levels of IL-6

cAMP

PGE-2 and TNF-α were slightly higher in the moderate heat group. There were significant differences between different primary diseases in the distribution of 7 immune parameters except PEG-2（ P < 0. 01）. The immune parameters were slightly higher in the pneumonia group. There was a significant difference between different disease duration in the IL-8 level（ P < 0. 05）. The IL-8 level was the highest in the1 st week of onset. The immune parameters were slightly higher in the wind pathogen group（ P < 0. 01）. Conclusion The immune parameters in patients with infectious diseases are often increased and with a certain relationship between body temperature

primary diseases

disease duration and TCM syndromes.