Characteristic Analysis of Biological Samples from 2 445 Patients with Infectious Diseases

WANG Lianxin; XIE Yanming; CHANG Yanpeng; YOU Li; LU Pengfei

doi:10.13288/j.11-2166/r.2014.20.019

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Characteristic Analysis of Biological Samples from 2 445 Patients with Infectious Diseases

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- Characteristic Analysis of Biological Samples from 2 445 Patients with Infectious Diseases
- Journal of Traditional Chinese Medicine Vol. 55, Issue 20, Pages: 1781-1785(2014)
- 作者机构：
  
  1. 中国中医科学院中医临床基础医学研究所
  2. 沈阳市骨科医院
  3. 中国人民大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.20.019
  CLC： R285.6
- Published：2014
- 稿件说明：
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[1]王连心,谢雁鸣,常艳鹏,尤丽,卢鹏飞.2445例感染性疾病患者生物样本基本特征分析[J].中医杂志,2014,55(20):1781-1785.

WANG Lianxin, XIE Yanming, CHANG Yanpeng, et al. Characteristic Analysis of Biological Samples from 2 445 Patients with Infectious Diseases[J]. Journal of Traditional Chinese Medicine2014, 55(20): 1781-1785.
[1]王连心,谢雁鸣,常艳鹏,尤丽,卢鹏飞.2445例感染性疾病患者生物样本基本特征分析[J].中医杂志,2014,55(20):1781-1785. DOI： 10.13288/j.11-2166/r.2014.20.019.

WANG Lianxin, XIE Yanming, CHANG Yanpeng, et al. Characteristic Analysis of Biological Samples from 2 445 Patients with Infectious Diseases[J]. Journal of Traditional Chinese Medicine2014, 55(20): 1781-1785. DOI： 10.13288/j.11-2166/r.2014.20.019.

摘要

目的探讨感染性疾病患者性别、年龄、地域、季节的基本特征及对免疫毒理学指标的影响。方法采用前瞻性、多中心、大样本、注册登记式研究方法

收集使用喜炎平注射液、痰热清注射液、热毒宁注射液3种清热解毒类中药注射剂的2445例患者

制定《喜炎平/热毒宁/痰热清注射液基本信息表》

包括患者性别、年龄、地域、季节情况

并采集患者血液样本

检测血清环磷酸腺苷（cAMP）、白细胞介素1β（IL-1β）、白细胞介素4（IL-4）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、巨噬细胞炎性蛋白1β（MIPL-1β）、前列腺素E2（PGE2）、肿瘤坏死因子-α（TNF-α）水平。结果 2445例患者中

男性占63.1%

以18岁以下儿童居多

北方地区人数略多

春季患者居多。女性患者IL-1β、cAMP、MIPL-1β、PGE2、TNF-α高于男性（P<0.05或P<0.01）

儿童患者各项指标均高于其他年龄患者

北方患者IL-1β、IL-4、IL-6、IL-8、cAMP、TNF-α高于南方患者

夏季患者IL-1β、IL-8、cAMP、PGE2和TNF-α高于其他季节（P<0.01）。结论不同年龄、性别、地域与发病季节感染性疾病患者免疫毒理学指标有所不同

其可能成为影响临床诊疗决策的混杂因素。

Abstract

Objective To study the basic features of gender

age

region and season in patients with infectious diseases and the effects on immune toxicology. Methods A prospective

multi-center

large sample and registered study was conducted. A total of 2 445 patients injected with Xiyanping Injection

Tanreqing Injection and Reduning Injection were collected. A basic information table of Xiyanping Injection

Tanreqing Injection and Reduning Injection was formulated. The patient information such as gender

age

geographic region and onset season was included in the table. The blood samples from patients were collected to detect the levels of cyclic adenosine monophosphate（ CAMP）

interleukin-1β（ IL-1β）

interleukin-4（ IL-4）

interleukin-6（ IL-6）

interleukin-8（ IL-8）

macrophage inflammatory protein-1β（ MIP-1β）

prostaglandin E2（ PGE2） and tumor necrosis factor-α（ TNF-α）. Results In2 445 patients

males accounted for 63. 1%. Most patients are children under 18 years old and from the northern region. The diseases commonly appeared in the spring. The levels of IL-1β

CAMP

MIP-1β

PGE2 and TNF-α in female patients were higher than those in male patients（ P < 0. 05 or P < 0. 01）. The levels of the indicators in pediatric patients were higher than those in other age（ P < 0. 01）. The levels of IL-1β

IL-4

IL-6

IL-8

CAMP and TNF-α in patients from the northern region were higher than those in patients from the southern region（ P < 0. 01）. The levels of IL-1β

IL-8

CAMP

PGE2 and TNF-α in patients who caught the diseases in summer were higher than those in patients who suffered the diseases in other seasons（ P < 0. 01）. Conclusion The indicators of immune toxicology in patients with infectious diseases vary in age

gender

geographic region and onset season. It may become the confounding factors influencing the clinical diagnosis and treatment decisions.

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