Clinical Observation on Liver-Nourishing Enzyme-Declining Mixture for 40 Cases of Chronic Hepatitis B

ZHANG Qian’e; XIE Hongwu; LIU Fushui

doi:10.13288/j.11-2166/r.2014.22.012

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Clinical Observation on Liver-Nourishing Enzyme-Declining Mixture for 40 Cases of Chronic Hepatitis B

更新时间：2021-11-17

- Clinical Observation on Liver-Nourishing Enzyme-Declining Mixture for 40 Cases of Chronic Hepatitis B
- Journal of Traditional Chinese Medicine Vol. 55, Issue 22, Pages: 1929-1932(2014)
- 作者机构：
  
  1. 湖北民族学院附属民大医院
  2. 江西中医药大学附属医院
  3. 江西中医药大学针灸学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.22.012
  CLC： R259
- Published：2014
- 稿件说明：
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[1]张千娥,谢洪武,刘福水.柔肝降酶合剂治疗慢性乙型肝炎40例临床观察[J].中医杂志,2014,55(22):1929-1932.

ZHANG Qian’e, XIE Hongwu, LIU Fushui. Clinical Observation on Liver-Nourishing Enzyme-Declining Mixture for 40 Cases of Chronic Hepatitis B[J]. Journal of Traditional Chinese Medicine2014, 55(22): 1929-1932.
[1]张千娥,谢洪武,刘福水.柔肝降酶合剂治疗慢性乙型肝炎40例临床观察[J].中医杂志,2014,55(22):1929-1932. DOI： 10.13288/j.11-2166/r.2014.22.012.

ZHANG Qian’e, XIE Hongwu, LIU Fushui. Clinical Observation on Liver-Nourishing Enzyme-Declining Mixture for 40 Cases of Chronic Hepatitis B[J]. Journal of Traditional Chinese Medicine2014, 55(22): 1929-1932. DOI： 10.13288/j.11-2166/r.2014.22.012.

摘要

目的观察柔肝降酶合剂治疗慢性乙型肝炎的临床疗效和安全性。方法将80例慢性乙型肝炎患者随机分为治疗组和对照组各40例

治疗组给予柔肝降酶合剂

每次30ml

每日3次。对照组给予甘草酸二铵肠溶胶囊

每次3粒

每日3次。两组均治疗3个月观察患者临床疗效

比较两组患者治疗前后中医症状积分

检测治疗前后两组患者丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、α-谷氨酰转肽酶（GGT）水平

观察不良反应。结果治疗组临床疗效总有效率为82.5%

对照组为75.0%

治疗组优于对照组（P<0.05）;两组患者治疗后食欲不振、脘闷腹胀、倦怠乏力、胁肋疼痛、腰膝酸软、五心烦热积分均较治疗前明显降低（P<0.05）

治疗组改善更显著（P<0.05）。两组患者治疗后ALT、AST、GGT水平较本组治疗前均有明显降低（P<0.05）

治疗组改善程度更显著（P<0.05）;治疗组安全性指标正常例数多于对照组（P<0.05）。结论柔肝降酶合剂治疗慢性乙型肝炎能改善患者临床症状及肝功能指标

且安全性高。

Abstract

Objective To observe the efficacy and safety of Liver-Nourishing Enzyme-Declining Mixture（ LEM）on chronic hepatitis B. Methods Totally 80 cases of chronic hepatitis B were randomized into the treatment group and control group

with 40 in each. The treatment group was given LEM

30 ml /time and 3 times daily. The control group was given Diammonium Glycyrrhizinate Enteric-Coated Capsules

3 capsules /time and 3 times daily. The treatment course in both groups lasted for 3 months. The efficacy was observed

the TCM symptom score was compared and the levels of alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST） and α-glutamyl transpeptidase（ GGT） were detected. The adverse reactions were observed. Results The total effective rate of the treatment group and control group were 82. 5% and 75. 0% respectively

with a significant difference between groups（ P <0. 05）. After treatment

the scores of poor appetite

epigastric distension and depression

lassitude

rib-side pain

soreness and weakness of waist and knees

and dysphoria in chestpalms-soles were significantly decreased in both groups（ P < 0. 05）

especially in the treatment group（ P < 0. 05）. The levels of ALT

AST and GGT in both groups were significantly improved after treatment（ P < 0. 05）

especially in the treatment group（ P < 0. 05）. The number of cases with normal safety index in the treatment group was larger than those in the control group（ P < 0. 05）.Conclusion LEM is effective and safe for chronic hepatitis B.

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Institute of Liver Diseases,Henan University of Chinese Medicine

Institute of Liver Diseases,Shanghai University of Chinese Medicine

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