Objective To evaluate the efficacy of Fuzheng Chuyi Granules against the infection of influenza A virus H1N1. Methods We randomly divided 112 mice into normal control group

virus model group

tamiflu control group and Fuzheng Chuyi group

28 rats in each group. Once per day for 7 days

normal control group and virus model group was given normal saline 0. 4 ml each

tamiflu control group was given tamiflu’s aqueous solution 0. 025 g /（ kg·d） and Fuzheng Chuyi group Fuzheng Chuyi Granules’ aqueous solution 12 g /（ kg·d） all by intragastric administration. On day 3

all groups except normal control group was induced by nose dripping H1N1 seasonal influenza virus mice lung adapted strain FM1-6-E2（ infection dosage 5LD50

50 μl each） and continued medication 1 hour after modeling. After infection day

took 10 mice out of each group to observe the mortality for 14 days. The rest 18 mice were calculated on lung index

tested for virus titer and observed on pathological changes of lung tissue on day3

6

9 after infection. Results 10 mice in virus model group all died

while 10 mice in tamiflu control group and in Fuzheng Chuyi group didn’t die. On day 9 after infection

comparing tamiflu control group

Fuzheng Chuyi group with virus model group

lung index was significantly lower（ P < 0. 05 or P < 0. 01）. On day 3

6 after infection

comparing tamiflu control group

Fuzheng Chuyi group with virus model group

virus titer of lung tissue was obviously lower（ P < 0. 05 or P < 0. 01）. Pathological changes of lung tissue in tamiflu control group and Fuzheng Chuyi group were minor and degree of inflammation was notedly less severe than that of virus model group. Conclusion Fuzheng Chuyi Granules has protective effect against mice death after infection of influenza A virus H1N1 and suppressed influenza virus’ s replication in the host.