Objective To explore the signaling mechanism of moxibustion at points Liangmen（ ST21） and Zusanli（ ST36） for promoting damage repair on gastric mucosa. Methods Forty-five rats were randomly divided into a normal group（ 10 rats）

a model group（ 15 rats）

a stomach meridian acupoint group（ 10 rats）

and a control acupoint group（ 10 rats）. Cold restrain stress method was applied on each group except normal group to make stress gastric ulcer rat model. On the 2nd day after modeling

rats in the stomach meridian acupoint group were astricted to rat boards and applied moxibustion at points Liangmen（ ST21） and Zusanli（ ST36）

while the rats of control acupoint group were given moxibustion at control points which located at 0. 5 cm beside Liangmen（ ST21） and Zusanli（ ST36）. The treatment lasted for 20 min each time

once daily for 12 days for both groups. Rats in the normal group and the model group were just astricted to rat boards. Levels of signaling protein phosphorylation in gastric mucosal cell were detected with Master Antibody Microarray Slides in each group. Results Compared with the model group

levels of 18 protein’ s phosphorylation in the stomach meridian acupoint group were down-regulated

among which the decreased levels of 5 protein’s phosphorylation（ TRAF2

Stat1

p53

Mkp-3 and NF-KB） showed statistically differences（ P < 0. 05 or P < 0. 01）. Levels of twenty nine protein’s phosphorylation were up-regulated

among which

the increasing levels of MEK

Ras

P38 MAPK

PI3K

PAK

B-Raf and ERK2 showed statistical significance（ P < 0. 05 or P < 0. 01）. Conclusion Moxibustion at Liangmen（ ST21） and Zusanli（ ST36） may regulate multiple related signaling protein phosphorylation levels and promote damage repair of gastric mucosa.