Objective To discuss the possible mechanisms of ulcer healing process with Weiyan Yin（ decoction for gastritis）. Methods Totally 40 Wistar rats were randomly assigned to sham-operation group

model group

Weiyan Yin high-dose group

Weiyan Yin low-dose group and omeprazole group with 8 in each group. Except for sham-operation group

acetic acid corrosion method was adopted to make gastric ulcer rat models. After 3 days

Weiyan Yin high-dose group and Weiyan Yin low-dose group were given Weiyan Yin 10 ml / kg by the concentration of 2. 14

1. 07 g / ml

while omeprazole group was given omeprazole liquid 10 ml / kg by the concentration of 0. 368 mg / ml.Sham-operation group and model group were given the same amount of normal saline. After the 14-day treatment

the ulcer condition was observed by naked eyes. The area of the gastric ulcer was measured and the inhibiting rate of ulcer was calculated. The expression of epidermal growth factor（ EGF）

vascular endothelial growth factor（ VEGF） and VEGF mRNA was detected. Results The ulcer area for the model group

Weiyan Yin high-dose group

Weiyan Yin low-dose group

omeprazole group was（ 26. 8 ± 9. 99） mm2

（ 10. 0 ± 4. 62） mm2

（ 19. 5 ± 6. 02） mm2

（ 17. 5 ±6. 18） mm2

respectively. Ulcer area in all treatment groups was significantly reduced compared with the model group（ P < 0. 05 or P < 0. 01） and ulcer area of Weiyan Yin high-dose group was smaller than that of Weiyan Yin low-dose group and omeprazole group（ P < 0. 05）. Compared to the sham-operation group

the average luminasity value of EGF and VEGF expression in the model group was significantly higher

while the average gray value was lower（ P <0. 05 or P < 0. 01）. The average luminasity value was significantly higher in all treatment groups than in the model group

while the average gray value was lower（ P < 0. 05 or P < 0. 01）. Weiyan Yin high-dose group was superior to Weiyan Yin low-dose group and omeprazole group（ P < 0. 05 or P < 0. 01）. The expression of EGF mRNA

VEGF mRNA in the model group was significantly higher than that of the sham-operation group（ P < 0. 05 or P < 0. 01）.The expression of EGF mRNA

VEGF mRNA in all treatment groups was higher than that of the model group

and Weiyan Yin high-dose group was superior to Weiyan Yin low-dose group and omeprazole group（ P < 0. 05 or P <0. 01）. Conclusion Weiyan Yin may promote the process of gastric mocusa recovering and ulcer healing by up-regulating the expression of growth factors on gastric mocusa in rats.