Objective To observe the clinical curative effect of Xiaopi Yuwei Decoction combined with Weifuchun Tablets in treatment of chronic atrophic gastritis with intestinal metaplasia or dysplasia. Methods In total 114 patients were randomly divided into a treatment group of 64 cases and a control group of 50 cases. Both groups were given Weifuchun Tablets orally

0. 359 g per tablet

4 tablets each time

3 times a day

while the treatment group was added with Xiaopi Yuwei Decoction

one dose daily. Both groups were treated for 3 courses

with 4 weeks as one course. The TCM symptom scores

pathological scores of gastric mucosa and Helicobacter pylori（ Hp） negative rates were compared before and after treatment to determine the clinical efficacy. Results The effective rate of the treatment group was 92. 2%

which was better than the 72% of the control group（ P < 0. 05）. After the treatments

the scores of epigastric fullness

epigastric pain

belching

acid reflux

stomach noises

and food intake were significantly improved in the treatment group（ P < 0. 01）; the scores of epigastric pain

belching

acid reflux

and stomach noises were improved but the scores of epigastric fullness and food intake showed no changes in the control group（ P >0. 05）

with the significant differences in scores of epigastric fullness and food intake between the two groups. The scores of gastric atrophy

intestinal metaplasia and dysplasia were significantly better after treatement in both groups（ P < 0. 05 or P < 0. 01）. Hp negative rate of the treatment group（ 46. 9%） was significantly higher than the control group（ 16. 7%

P < 0. 05）. Conclusion Xiaopi Yuwei Decoction with Weifuchun Tablets could significantly improve the symptoms

as well as reduce the gastric mucosal injuries in the treatment of chronic atrophic gastritis with intestinal metaplasia or dysplasia.