Objective To analyze the syndrome regularity of drug-induced liver injury（ DILI） and to provide basis for treatment based on syndrome differentiation. Methods Collected clinical data of 1119 patients with DILI

including age

sex

disease type

clinical symptoms and signs of traditional Chinese medicine（ fatigue

poor appetite

sickness of oily food

yellow urine

yellowish discoloration of body

nausea

abdominal distension

abdominal pain

fever

hepatomegaly

vomiting

skin itching

skin rash and others

totally 23 items）. Adopted frequency description and Logistic regression analysis method to investigate TCM symptom characteristics and its distribution of liver cell damage pattern

cholestasis pattern and mixed pattern of the DILI patients. Results Among 1119 DILI patients

746 cases belong to liver cell damage pattern

233 cases belong to cholestasis pattern

and 140 cases belong to mixed pattern. Symptoms such as fatigue

yellow urine

poor appetite

yellow eyes

yellow body and nausea have higher frequency accounted for 60. 14%

57. 82%

42. 72%

42. 63%

27. 61%

16. 35%

respectively. Logistic regression analysis showed poor appetite

sickness of the oily food

nausea

and fever have greater correlation with the hepatocyte injury pattern; skin itching has greater correlation with cholestasis pattern; yellow urine

yellowish discoloration of body

and poor appetite have greater correlation with the mixed pattern of hepatic injury. Conclusion DILI of liver cell injury type mainly belong to liver stagnation and spleen deficiency pattern

liver-stomach disharmony pattern

and cholestasis type is frequently seen in liver-gallbladder damp-heat pattern; DILI of mixed type may involve the liver stagnation and spleen deficiency pattern

and lower-jiao damp-heat pattern

liver-stomach disharmony pattern

and damp heat in liver and gallbladder dampness heat in lower-jiao pattern.