Objective To evaluate the clinical effect of Yisui Shengxue Keli on patients of β-thalassemia.Methods Yisui Shengxue Keli was adopted to treat 281 β-thalassemia patients

including β-thalassemia major 63 cases（ hemoglobin E / β-thalassemia major 18 cases and simple β-thalassemia major 45 cases） and β-thalassemia intermedia 218 cases（ hemoglobin E / β-thalassemia intermedia 35 cases and simple β-thalassemia intermedia 183cases）. Each patient was treated for 3 months. Hemoglobin（ Hb）

red blood cells（ RBC）

reticulated corpuscles（ Ret） and fetal hemoglobin（ Hb F） of 281 patients before and after treatment were compared. Quantify and score traditional Chinese medicine（ TCM） syndrome（ sallow complexion

dizziness

palpitation

asthma when moving

lassitude

anorexia） of 147 β-thalassemia patients before and after treatment

and observe the clinical effect.Results After treatment

Hb

RBC and Hb F of four types β-thalassemia patients increased evidently（ P < 0. 01）;Ret of hemoglobin E / β-thalassemia major patients had no obvious change（ P > 0. 05）; while Ret of simple β-thalassemia major

hemoglobin E / β-thalassemia intermedia and simple β-thalassemia intermedia patients increased evidently（ P < 0. 01）. Quantization score of TCM symptoms including sallow complexion

dizziness

palpitation

asthma when moving

lassitude and anorexia) of β-thalassemia intermedia patients decreased obviously（ P < 0. 01）; the palpitation

asthma when moving

lassitude and anorexia scores of β-thalassemia major patients decreased significantly（ P <0. 05 or P < 0. 01）. Among 281 patients

effective cases were 213

accounting for 75. 80% including 34 effective cases in 45 patients of simple β-thalassemia major

accounting for 75. 56%; 16 effective cases in 18 patients of hemoglobin E / β-thalassemia major

account for 88. 89%; 131 effective cases in 183 patients of β-thalassemia intermedia

accounting for 71. 58%; 32 effective cases in 35 patients of Hemoglobin E / β-thalassemia intermedia

accounting for91. 43%. Conclusion Yisui Shengxue Keli had significant therapeutic effect on different types of β-thalassemia.Improvements of patients’ clinical symptoms consist with the changes of blood indexes.