Objective To observe the clinical effect the treatment with Yishen Angong Formula combined with progesterone injection on threatened abortion. Methods Totally 100 cases of threatened abortion patients were randomly divided into treatment group and control group

with 50 cases in each group. In the control group

patients were given intramuscular injection of progesterone injection 40 mg

1 time per day. According to TCM syndrome differentiation

patients in the treatment group were divided into kidney deficiency and blood heat pattern and the kidney and spleen deficiency pattern

and were given prescription No. 1 and No. 2 of Yishen Angong Formula respectively

one dose per day. For the two groups

set 7 days as one course

and totally treated with 3 courses. The levels of serum chorionic gonadotropin（ beta-HCG）

progesterone（ P）

estradiol（ E2） were tested in both groups before treatment

and 1

2

3 weeks after treatment. The TCM syndrome score will be compared in two groups before and after treatment. After treatment

evaluated the comprehensive efficacy and syndrome efficacy

then evaluated the clinical comprehensive therapeutic effect in the treatment group among patients with different age

different history of natural abortion and different gestational weeks. Results In the treatment group and the control group

the total effective rates of the clinical curative effect are respectively 88% and 72%

and the treatment group was significantly better than the control group（ P < 0. 05）. After treatment

the TCM syndrome score of the two groups was significantly lower than those before treatment（ P < 0. 01）; and after treatment

TCM syndrome score of the control group was significantly lower than the control group（ P < 0. 05）. One

two

three weeks after the treatment

the serum-HCG

E2 levels of the patients in both groups were significantly increased compared with those before treatment（ P < 0. 01）. In the treatment group

one

two

three weeks after the treatment

the serum level of P increased significantly compared with those before treatment(（ P < 0. 01 or P < 0. 05）

and in the control group

one

two

three weeks after the treatment

the level of serum P obviously rose than those before treatment（ P < 0. 01）; One

two

three weeks after the treatment

the serum levels of E2 in treatment group were significantly higher than in the control group（ P <0. 01）. Comparing patients with different ages

different histories of natural abortion

and gestational weeks in the treatment group

it showed that the differences of the total curative effect were not statistically significant（ with P >0. 05）. Conclusion The treatment of Yishen Angong Formula combined with progesterone injection in threatened abortion has exact curative effect

which is not affected by patient age

history of spontaneous abortion

gestational weeks. It can significantly improve the clinical TCM symptoms and raise the serum level of E2.