Objective To comprehensively analyze ZHU Danxi’ s medication regularity through objective data mining. Methods Collect the standard formulas in Danxi Xinfa（ 丹溪心法） and establish the database of ZHU Danxi’s formulas and medicines

normalize the medicine names

and then analyze the medicines with frequency. To classify the statistics by hierarchical clustering

and by using the Carma method

to analyze the assotionations between the Chinese medicines. Results Totally 610 formulas were enrolled in this study and involved 337 Chinese medicines. The top 10 Chinese medicines most frequently used are Fulin（ Poria cocos）

Shengjiang（ Fresh ginger）

Zhigancao（ Radix glycyrrhizae preparata）

Gancao（ Glycyrrhiza uralensis）

Chenpi（ Pericarpium citri reticulatae）

Renshen（ Ginseng）

Banxia（ Pinellia ternata）

Baizhu（ Atractylodes）

Danggui（ Chinese Angelica）

Chuanxiong（ Ligusticum wallichii）. The 12 central medicinal pairs analyzed by clustering are Sharen（ Fructus amomi） with Huoxiang（ Agastache rugosus）

Xixin（ Asarum sieboldi mig.） with Baizhi（ Angelica dahurica）

Dannanxing（ Arisaema cum bile） with Zhishi（ Fructus aurantii immaturus）

Shengma（ Cimicifuga foetida） with Chaihu（ Radix bupleuri）

Fangfeng（ Radix saposhnikoviae） with Qianghuo（ Notopterygium incisum）

Huangbai（ Phellodendron amurense） with Zhimu（ Anemarrhena asphodeloides）

Houpo（ Mangnolia officinalis） with Cangzhu（ Atractylodes lancea）

Jiegeng（ Platycodon grandiflorum） with Zhiqiao（ Fructus aurantii）

Shudihuang（ Radix rehmanniae praeparata） with Shengdihuang（ Radix Rehmanniae Recens）

Huangqin（ Scutellaria baicalensis） with Huanglian（ Coptis chinensis）

Baizhu with Renshen（ Ginseng）

and Chenpi（ Pericarpium citri reticulatae） with Banxia（ Pinellia ternata）. Set a support degree with 3% and a confidence coefficient with 65%

and then 39 associated pairs were screened of which the upgrading was greater than one. Conclusion In ZHU Danxi’s experience

he made good use of reinforcing spleen medicine

and made the regulating spleen and stomach medicines as the core. It prompts that in ZHU Danxi’ s academic thoughts

not only nourishing yin is priority

but also regulating spleen and stomach is emphasized.