Objective To observe the clinical efficacy and safty of Pinggan Jianpi Fang（ PJF） in treating Tourette syndrome. Methods Totally 100 children patients with Tourette syndrome were randomly into an observation group and a control group

50 cases in each group. The observation group was given PJF formula granule

one dose daily. The control group was oral haloperidol tablet starting from a small dose with 0. 05 mg /（ kg·d）

and the dose would be appropriately adjusted depending on patients’ condition and therapeutic effect. In the two groups

the treatment takes 30 days as one course

and in total lasted for 3 courses. The episode times

frequency and intensity of the two group children patients before treatment and treating for 30

60

90 days would be graded according to Yale Global Tic Severity Scale（ YGTSS）. The clinical efficacy was also evaluated and the untoward effect was observed during the treatment. Results Complying the project to treat for 30

60

90 days

the total effective rates were41. 3%

63. 0% and 76. 1% respectively in the observation group

and 59. 1%

63. 6% and 77. 3% in the control group. The control group was significantly better than the observation group in the 30-day treatment（ P < 0. 05）

and no obvious differences in other points in time（ P > 0. 05）. The twitch time

frequency and intensity scores in the two groups treating for 30

60

90 days were significantly reduced than those before treatment（ P < 0. 05）. The control group was much improved than the observation group in the 30-day treatment（ P < 0. 05）

and no obvious differences in 60

90-day treatment（ P > 0. 05）. Compared with the control group

the untoward effect occurrence rate was lower with mild degree in the observation group. Conclusion The PJF seemed working more slowly than haloperidol tablet in treating Tourette syndrome

while with the same late result and higher security.