Objective To observe the clinical efficacy of Xinshuai Heji（ XH） combined with western medicine in treating dilated cardiomyopathy with heart failure. Methods Totally 85 dilated cardiomyopathy patients with heart failure were randomly divided into a treatment group with 43 cases and a control group with 42 cases. Both groups were given conventional treatments for heart failure. Meanwhile

the treatment group was also given XH

twice per day

25 ml each time. After continual treatments for 3months

the clinical symptoms

signs and heart functional classification before and after treatments in the two groups were observed and the clinical efficacies were evaluated.The plasma transforming growth factor β1（ TGF-β1） and brain natriuretic peptide（ BNP） contents were tested before treatment and treating for 2 weeks. The left ventricular end diastolic diameter（ LVEDD）

left ventricular end systolic diameter（ LVESD）

left ventricular ejection fraction（ LVEF） and fraction shortening（ FS） were examined before treatment and treating for 2 weeks

3 months. Results The total effective rates at the 2-week and 3-month treatment in the treatment group were 90. 7% and 97. 7% respectively

while 80. 9% and 88. 1% in the control group.The treatment group was significantly better than the control group（ P < 0. 05）. At the treatment for 2 weeks and 3months

the LVEDD and LVESD were significantly diminished and the LVEF and FS were markedly improved in the treatment group（ P < 0. 05 or P < 0. 01）

and LVEF was significantly increased in the control group（ P < 0. 05）.Compared with the control group

LVESD in the treatment group was obviously diminished after treating for 2 weeks and 3 months（ P < 0. 05）

FS in the treatment group was markedly higher after treating for 3 months（ P < 0. 05）.The BNP and TGF-β1 contents were significantly reduced in the two groups after treating for 2 weeks than before（ P <0. 05 or P < 0. 01）

and the treatment group was much lower than the control group（ P < 0. 05）. Conclusion The XH combined with western medicine could improve the heart function in dilated cardiomyopathy patients with heart failure

which might be connected with left ventricle remodeling.