Connotation between prescription and syndrome in traditional Chinese medicine means to differentiate the relationship of prescription and syndrome according to patients’ objective symptoms and signs. In fact

objective indication for prescription is emphasized. The premise of prescription is deep comprehension of classical previsions.The point of prescription and syndrome is understanding original texts

ascertaining primary and secondary symptoms and signs

and differentiating between the important and the lesser one. The phenomena of one prescription for many syndromes and many prescriptions for one syndrome are common in ZHANG Zhongjing’ s Treatise on Febrile and Miscellaneous Diseases（ 伤寒杂病论）. The problem in classical prescriptions application may be solved by establishing integration of symptoms

syndromes and prescriptions

which includes categorizing syndromes according to meridians

prescribing according to therapeutic methods

and differentiating analogous prescriptions carefully.