Correlations between Resistin,Leptin,Adiponectin and Liver Stagnation and Spleen Deficiency Syndrome in Type 2 Diabetic Patients

WANG Lei; LIU Tonghua; QIN Lingling; WANG Fen; GAO Jing; ZHANG Liping; XIAO Ruoran; LOU Xi’en

doi:10.13288/j.11-2166/r.2015.15.011

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Correlations between Resistin,Leptin,Adiponectin and Liver Stagnation and Spleen Deficiency Syndrome in Type 2 Diabetic Patients

更新时间：2021-11-17

- Correlations between Resistin,Leptin,Adiponectin and Liver Stagnation and Spleen Deficiency Syndrome in Type 2 Diabetic Patients
- Journal of Traditional Chinese Medicine Vol. 56, Issue 15, Pages: 1298-1301(2015)
- 作者机构：
  
  1. 北京中医药大学第三附属医院
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2015.15.011
  CLC： R259
- Published：2015
- 稿件说明：
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[1]王磊,刘铜华,秦灵灵,王芬,高晶,张丽萍,肖若然,娄锡恩.抵抗素、瘦素、脂联素与2型糖尿病患者肝郁脾虚证的相关性[J].中医杂志,2015,56(15):1298-1301.

WANG Lei, LIU Tonghua, QIN Lingling, et al. Correlations between Resistin,Leptin,Adiponectin and Liver Stagnation and Spleen Deficiency Syndrome in Type 2 Diabetic Patients[J]. Journal of Traditional Chinese Medicine2015, 56(15): 1298-1301.
[1]王磊,刘铜华,秦灵灵,王芬,高晶,张丽萍,肖若然,娄锡恩.抵抗素、瘦素、脂联素与2型糖尿病患者肝郁脾虚证的相关性[J].中医杂志,2015,56(15):1298-1301. DOI： 10.13288/j.11-2166/r.2015.15.011.

WANG Lei, LIU Tonghua, QIN Lingling, et al. Correlations between Resistin,Leptin,Adiponectin and Liver Stagnation and Spleen Deficiency Syndrome in Type 2 Diabetic Patients[J]. Journal of Traditional Chinese Medicine2015, 56(15): 1298-1301. DOI： 10.13288/j.11-2166/r.2015.15.011.

摘要

目的探讨抵抗素、瘦素、脂联素与2型糖尿病患者肝郁脾虚证的相关性。方法将2型糖尿病患者59例按中医辨证标准分为肝郁脾虚组（29例）、非肝郁脾虚组（30例）

另设正常对照组28例。收集各组受试者临床资料

包括身高、体重、腹围等

计算体重指数（BMI）

检测空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HBAlc）、血清空腹胰岛素水平（FINS）、餐后2 h胰岛素水平（2 h PINS）、胰岛素抵抗指数（HOMA-IR）、抵抗素、瘦素、脂联素水平

各指标间的相关性分析采用Pearson相关性分析。结果与正常对照组比较

肝郁脾虚组及非肝郁脾虚组患者BIM、腹围、抵抗素、瘦素水平明显升高

而脂联素水平明显降低（P<0.05或P<0.01）。肝郁脾虚组患者瘦素水平高于非肝郁脾虚组

而脂联素水平低于非肝郁脾虚组（P<0.05）。肝郁脾虚组与非肝郁脾虚组比较

FINS、HOMA-IR差异具有统计学意义（P<0.05）。相关分析显示

瘦素与抵抗素呈正相关

瘦素与脂联素呈负相关

抵抗素与脂联素呈负相关

均有统计学意义（P<0.05）。结论 2型糖尿病肝郁脾虚证患者与高瘦素、低脂联素相关。

Abstract

Objective To investigate the correlations between resistin

leptin

adiponectin and liver stagnation and spleen deficiency syndrome in type 2 diabetic patients. Methods Fifty-nine cases of type 2 diabetic patients were grouped into liver stagnation and spleen deficiency group of 29 cases and non liver stagnation and spleen deficiency syndrome group of 30 cases according to TCM syndrome differentiation standard

and a normal control group of 28 cases was set also. The clinical data of each group was collected

including height

weight

abdominal circumference

body mass index（ BMI） was calculated

fasting blood glucose（ FBG）

postprandial 2H plasma glucose（ 2h PG）

glycosylated hemoglobin（ Hb Alc）

serum fasting insulin（ FINS）

postprandial 2H insulin level（ 2h PINS）

insulin resistance index（ HOMA-IR）

resistin

leptin and adiponectin level were tested. Correlation analysis between the indicators is analyzed by Pearson method. Results Compared with the normal control group

BMI

abdominal circumference

resistin and leptin levels were significantly increased

and adiponectin levels decreased significantly（ P < 0. 05 or P < 0. 01） in liver stagnation and spleen deficiency group and non liver stagnation and spleen deficiency group. Serum leptin levels of patients in liver stagnation and spleen deficiency group is higher than that in the non-liver stagnation and spleen deficiency group

however the adiponectin level is lower than that in the non-liver stagnation and spleen deficiency group（ P < 0. 05）. Compared with the non-liver stagnation and spleen deficiency group

FINS

HOMA-IR difference in liver stagnation and spleen deficiency group was statistically significant（ P < 0. 05）. Correlation analysis showed that leptin and resistin was positively related

leptin and adiponectin was negatively correlated

resistin was negatively correlated with adiponectin

which were statistically significant（ P <0. 05）. Conclusion Type 2 diabetic patients with syndrome of liver stagnation and spleen deficiency seems related with high leptin and low adiponectin.

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