Correlation of Prognostic Determinants and Chinese Medicine Constitution Patterns in Non-Small Cell Lung Cancer Patients

CHEN Wenjun; TIAN Fei; XU Dongxin; LI Jinhua; YANG Liqin; LI Ruijie

doi:10.13288/j.11-2166/r.2015.18.011

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Correlation of Prognostic Determinants and Chinese Medicine Constitution Patterns in Non-Small Cell Lung Cancer Patients

更新时间：2021-11-17

- Correlation of Prognostic Determinants and Chinese Medicine Constitution Patterns in Non-Small Cell Lung Cancer Patients
- Journal of Traditional Chinese Medicine Vol. 56, Issue 18, Pages: 1569-1572(2015)
- 作者机构：
  
  1. 天津中医药大学
  2. 天津中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2015.18.011
  CLC： R734.2
- Published：2015
- 稿件说明：
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[1]陈文军,田菲,许冬鑫,黎金华,杨丽琴,李蕊洁.非小细胞肺癌患者预后影响因素与中医体质类型的相关性[J].中医杂志,2015,56(18):1569-1572.

CHEN Wenjun, TIAN Fei, XU Dongxin, et al. Correlation of Prognostic Determinants and Chinese Medicine Constitution Patterns in Non-Small Cell Lung Cancer Patients[J]. Journal of Traditional Chinese Medicine2015, 56(18): 1569-1572.
[1]陈文军,田菲,许冬鑫,黎金华,杨丽琴,李蕊洁.非小细胞肺癌患者预后影响因素与中医体质类型的相关性[J].中医杂志,2015,56(18):1569-1572. DOI： 10.13288/j.11-2166/r.2015.18.011.

CHEN Wenjun, TIAN Fei, XU Dongxin, et al. Correlation of Prognostic Determinants and Chinese Medicine Constitution Patterns in Non-Small Cell Lung Cancer Patients[J]. Journal of Traditional Chinese Medicine2015, 56(18): 1569-1572. DOI： 10.13288/j.11-2166/r.2015.18.011.

摘要

目的观察非小细胞肺癌（NSCLC）患者中医体质类型分布

探讨NSCLC患者中医体质与预后影响因素的关系。方法对NSCLC患者进行中医体质调查

并收集患者的性别、年龄、吸烟指数、病理类型等8个影响预后的因素

对患者中医体质分布及其与预后影响因素的相关性进行Logistic回归分析。结果纳入89例NSCLC患者

中医体质类型分别为阴虚质19例（21.3%）

痰湿质15例（16.9%）、气虚质14例（15.7%）、血瘀质14例（15.7%）、平和质10例（11.3%）、气郁质10例（11.3%）

湿热质3例（3.4%）、阳虚质2例（2.2%）、特禀质2例（2.2%）。回归分析显示

TNM分期与气虚质（B=0.951

P=0.010）、阴虚质（B=1.127

P=0.001）呈正相关

与血瘀质（B=-1.123

P=0.018）、痰湿质（B=-1.459

P=0.008）呈负相关;体重下降与阴虚质呈正相关（B=2.140

P=0.006）

与痰湿质呈负相关（B=-1.247

P=0.037）。性别、年龄、吸烟指数、病理类型、家族史、KPS评分与NCSLC患者的体质类型分布无显著相关性（P>0.05）。结论 NSCLC患者的体质类型以阴虚质、痰湿质、气虚质、血瘀质为主。在NSCLC预后因素中

TNM分期和体重下降状态与患者的中医体质类型分布具有相关性。

Abstract

Objective To observe the distribution of Chinese medicine constitutional patterns in non-small cell lung cancer（ NSCLC） patients and discuss the relation of patients’ constitutional patterns and prognostic determinants. Methods NSCLC patients’ constitutional patterns in Chinese Medicine were investigated and prognostic determinants

such as patients’ gender

age

smoking index

pathological type

etc. were collected. Logistic regression analysis was made to analyze the correlation between patients’ constitutional patterns distribution and prognostic determinants. Results There were 89 patients of NSCLC in total. 19 cases were of Yin deficiency type（ 21. 3%）

15 cases phlegm-dampness type（ 16. 9%）

4 cases Qi deficiency type 1（ 15. 7%）

14 cases blood stasis type（ 15. 7%）

10 cases normal type（ 11. 3%）

10 cases Qi stagnation type（ 11. 3%）

3 cases dampness-heat type（ 3. 4%）

2 cases Yang deficiency（ 2. 2%）

and 2 cases special type（ 2. 2%）. Regression analysis showed that there was positive correlation between TNM stage and Qi deficiency（ B = 0. 951

P = 0. 010） and Yin deficiency（ B = 1. 127

P = 0. 001） types and negative correlation between TNM stage and blood stasis（ B =- 1. 123

P =0. 018） and phlegm-dampness（ B =- 1. 459

P = 0. 008） types. There was positive correlation between weight loss and Yin deficiency type（ B = 2. 140

P = 0. 006）. There was negative correlation between weight loss and phlegmdampness type（ B =- 1. 247

P = 0. 037）. There was no significant correlation between patients’ constitutional patterns and gender

age

smoking index

pathological type

family history and KPS scores. Conclusion Patients’ constitutional patterns were main Yin deficiency

phlegm-dampness

Qi deficiency and blood stasis types. Among NSCLC prognostic determinants

TNM stage and weight loss had correlation with patients’ constitutional patterns.

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